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1-Substituted 2-Benzylaminobenzimidazoles with Phenyl Methoxyls: Synthesis, Computer Prediction, and Pharmacological Activity
Condensation of 1-substituted 2-aminobenzimidazoles with aromatic aldehydes produced the corresponding azomethines, reduction of which by sodium borohydride afforded 1-substituted
Synthesis and pharmacological activity of 3-(n,n-disubstituted)acetamide-1-r-2-aminobenzimidazolium chlorides
A series of 3-(N,N-disubstituted)acetamide-1-R-2-aminobenzimidazolium chlorides were synthesized. Their pharmacological properties were studied. It was established that the synthesized substances
Synthesis and pharmacological activity of 9-R-2-halogenophenylimidazo[1,2-a]benzimidazoles
Taking into account the structure—activity relationship established previously for imidazobenzimidazole derivatives with high hemorheological activity, several new 9-R-2-halogenophenyl-substituted
Synthesis and pharmacological activity of 1-dialkyl(alkyl)aminoethyl-2,3-dihydroimidazo[1,2-a]benzimidazoles
In continuation of the investigation of 1-dialkylaminoethyl-2,3-dihydroimidazo[1,2-a]benzimidazoles demonstrating serotoninergic activity, several new substances of this class with 4-substituted
Synthesis and pharmacological activity of aroylmethyl derivatives of tricyclic benzimidazole systems containing hydroxy groups in aroyl radicals
The synthesis and pharmacological properties of a series of aroylmethyl derivatives of tricyclic benzimidazole systems containing hydroxy groups in aroyl radicals are described. It is established
Synthesis and Antidiabetic Activity of Thiazolo[2,3-f]Purine Derivatives and Their Analogs
Thiazolo[2, 3-f]purine derivatives and their analogs – dihydrothiazolo[2, 3-f]purine, 7-(thietan-3-yl)purine, and 8-(2-hydroxypropylthio)purine derivatives – were synthesized. The compounds
Synthesis and pharmacological activity of 10-alkylaminoethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazoles
The synthesis of 10-chloroethyl-2,3,4,10-tetrahydropyrimido[1,2-a]benzimidazole was described. The nucleophilic substitution of the chlorine atom by various amines was studied. As a result,
Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid
Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro
Synthesis and antiaggregant activity of 8-amino-substituted 1-alkyl-3-methyl-7- (thietanyl-3)xanthines
A series of 8-amino-substituted 1-alkyl-3-methyl-7-(thietanyl-3)xanthines have been synthesized using 1-ethyl-, 1-propyl-, and 1-hexyl-8-bromo-3-methyl-7-(thietanyl-3)xanthines and various reactants
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