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In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
The ability of HIV-based viral vectors to deliver genes in vivo into nondividing cells could increase the applicability of retroviral vectors in human gene therapy. Expand
A Third-Generation Lentivirus Vector with a Conditional Packaging System
It is demonstrated that the requirement for the tat gene can be offset by placing constitutive promoters upstream of the vector transcript, and the improved design presented here should facilitate testing of lentivirus vectors. Expand
Self-Inactivating Lentivirus Vector for Safe and Efficient In Vivo Gene Delivery
The inactivation design achieved in this work improves significantly the biosafety of HIV-derived vectors, as it reduces the likelihood that replication-competent retroviruses will originate in the vector producer and target cells, and hampers recombination with wild-type HIV in an infected host. Expand
Multiply attenuated lentiviral vector achieves efficient gene delivery in vivo
- R. Zufferey, D. Nagy, R. Mandel, L. Naldini, D. Trono
- Biology, Medicine
- Nature Biotechnology
- 1 September 1997
An HIV vector system in which the virulence genes env, vif, vpr, vpu, and nef have been deleted is described, and this multiply attenuated vector conserved the ability to transduce growth-arrested cells and monocyte-derived macrophages in culture, and could efficiently deliver genes in vivo into adult neurons. Expand
Tie2 identifies a hematopoietic lineage of proangiogenic monocytes required for tumor vessel formation and a mesenchymal population of pericyte progenitors.
It is demonstrated that monocytes expressing the Tie2 receptor (Tie2-expressing monocytes [TEMs]) are a distinct hematopoietic lineage of proangiogenic cells that are selectively recruited to spontaneous and orthotopic tumors and promote angiogenesis in a paracrine manner. Expand
Viral vectors for gene therapy: the art of turning infectious agents into vehicles of therapeutics
Further vector refinement and/or development is required before gene therapy will become standard care for any individual disorder, and some clinical successes are over the horizon. Expand
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector.
- L. Naldini, U. Blömer, F. Gage, D. Trono, I. Verma
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 15 October 1996
Development of clinically acceptable derivatives of the lentiviral vector may enable the sustained delivery of significant amounts of a therapeutic gene product in a wide variety of somatic tissues. Expand
Identification of proangiogenic TIE2-expressing monocytes (TEMs) in human peripheral blood and cancer.
It is reported that TIE2 expression in human blood identifies a subset of monocytes distinct from classical inflammatory monocytes and comprised within the less abundant "resident" population of blood monocytes, suggesting a potentially critical role of TEMs in human cancer progression. Expand
Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke
Although ependymal cells act as primary cells in the neural lineage to produce neurons and glial cells after stroke, they do not fulfill defining criteria for stem cells under these conditions and instead serve as a reservoir that is recruited by injury. Expand
Gene transfer by lentiviral vectors is limited by nuclear translocation and rescued by HIV-1 pol sequences
The results indicate that nuclear translocation of the genome is a rate-limiting step in lentiviral infection of both dividing and non-dividing cells, and that it depends on protein and nucleic acid sequence determinants. Expand