• Publications
  • Influence
Osteogenic protein‐1, a bone morphogenetic protein, induces angiogenesis in the chick chorioallantoic membrane and synergizes with basic fibroblast growth factor and transforming growth factor‐β1
The present findings suggest that bone morphogenetic proteins, which are members of the TGF‐β superfamily, may be deployed in binary combination in order to accentuate experimental angiogenesis. Expand
Tissue engineering: TGF-beta superfamily members and delivery systems in bone regeneration.
The basis of bone tissue engineering by members of the TGF-beta superfamily is outlined, focusing on their delivery systems and the intrinsic induction of bone formation by specific biomimetic matrices with a defined geometry. Expand
Immunolocalization of Bone Morphogenetic Protein-2 and -3 and Osteogenic Protein-1 during murine tooth root morphogenesis and in other craniofacial structures.
The composite expression of BMPs/OPs during periodontal tissue morphogenesis suggests that optimal therapeutic regeneration may entail the combined use of different BMP-3 and OPs. Expand
Bone Induction by BMPs/OPs and Related Family Members in Primates: The Critical Role of Delivery Systems
This work focuses on the geometric induction of bone formation by sintered porous hydroxyapatite (SPHA) discs with concavities on their planar surfaces, which elicit bone formation without exogenously applied BMPs/OPs. Expand
Bone morphogenetic proteins in craniofacial and periodontal tissue engineering: experimental studies in the non-human primate Papio ursinus.
The bone morphogenetic and osteogenic proteins (BMPs/OPs), pleiotropic members of the transforming growth factor-beta (TGF-beta) supergene family act as soluble signals for the de novo initiation ofExpand
Periodontal tissue regeneration by recombinant human transforming growth factor-beta 3 in Papio ursinus.
Recombinant human transforming growth factor-beta 3 in Matrigel significantly enhanced periodontal tissue regeneration in the nonhuman primate, P. ursinus. Expand
Glucocorticoids, antioxidants and staurosporine modulate the adherence between monocytes and malaria infected erythrocytes
The adherence of malaria infected erythrocytes to monocytes is reduced in response to glucocorticoids (dexamethasone and cortisol), anti-oxidants (probucol and ambroxol), danazol and staurosporine. Expand
Transforming Growth Factor-β Supports the Rapid Morphogenesis of Heterotopic Endochondral Bone Initiated by Human Osteogenic Protein-1 via the Synergistic Upregulation of Molecular Markers
Histologically, single applications of OP-1 elicited a dose dependent induction of endochondral bone formation while the binary applications resulted in a temporal acceleration of the morphogenetic cascade. Expand
Biomimetic Smart Hydroxyapatite/Biphasic Tricalcium Phosphate Biomatrices Induce Bone Formation
Long-term studies in the non-human primate Papio ursinus were set to investigate the induction of bone formation in biphasic hydroxyapatite tricalcium phosphate (HA/TCP) biomimetic matrices, 20/80Expand