The human orphan receptor PXR messenger RNA is expressed in both normal and neoplastic breast tissue.
- Helmut Dotzlaw, E. Leygue, P. Watson, L. Murphy
- Medicine, BiologyClinical Cancer Research
- 1 August 1999
A statistically significant inverse relationship was found between the level of PXR mRNA expression and estrogen receptor (ER) status, as defined by ligand binding analysis, and the possibility that P XR has a role in human breast tissues is raised.
Putative functional characteristics of human estrogen receptor-beta isoforms.
Data support promoter-specific differential activities of hERbeta isoforms with respect to models of ERalpha regulated gene expression, and suggest that they may have a role in differentially modulating estrogen action.
Expression of oestrogen receptor-β in oestrogen receptor-α negative human breast tumours
- G. Skliris, E. Leygue, L. Curtis-Snell, P. Watson, L. Murphy
- Medicine, BiologyBritish Journal of Cancer
- 1 August 2006
It is shown that a range of ERβ isoform expression occurs in ERα-negative breast tumours, and individual forms show associations with certain phenotypes that suggest different roles in subsets of ER α-negative cancers.
Relationship of coregulator and oestrogen receptor isoform expression to de novo tamoxifen resistance in human breast cancer
- L. Murphy, E. Leygue, Y. Niu, L. Snell, S. Ho, P. Watson
- Biology, MedicineBritish Journal of Cancer
- 2 December 2002
There is little evidence for altered coregulators expression in breast tumours that are de novo tamoxifen resistant, but preliminary evidence that the expression of oestrogen receptor β protein isoforms may differ in primary tumours of breast cancer patients who prove to have differential sensitivity to tamoxIFen therapy is provided.
Estrogen receptor-beta mRNA variants in human and murine tissues.
- B. Lu, E. Leygue, Helmut Dotzlaw, L. Murphy, L. Murphy, P. Watson
- BiologyMolecular and Cellular Endocrinology
- 1998
Interestingly, no equivalent of the mouse inserted transcript was detected in any of the four human tissues analyzed, and in mouse tissues an ER-beta transcript containing 54 nucleotides inserted in frame between exons 5 and 6 was identified.
Expression of estrogen receptor-beta in human breast tumors.
- Helmut Dotzlaw, E. Leygue, P. Watson, L. Murphy
- BiologyJournal of Clinical Endocrinology and Metabolism
- 1 July 1997
The expression of a recently described novel estrogen receptor, ER-beta, was detected in several human breast tumor biopsy samples and severalhuman breast epithelial cell lines using reverse transcription and polymerase chain reaction (RT-PCR) analysis, supporting a possible role for ER- beta in human breast cancer.
Estrogen receptor-beta messenger RNA expression in human breast tumor biopsies: relationship to steroid receptor status and regulation by progestins.
- Helmut Dotzlaw, E. Leygue, P. Watson, L. Murphy
- Medicine, BiologyCancer Research
- 1 February 1999
The data suggest the possibility that expression of ER-beta in human breast tumors is a marker of endocrine therapy responsiveness and specifically decreased by progestin in T47D breast cancer cells.
Estrogen receptor variants in normal human mammary tissue.
- E. Leygue, P. Watson, L. Murphy
- Biology, MedicineJournal of the National Cancer Institute
- 6 March 1996
Several ER variant mRNAs are present in normal human breast tissue, but the level of expression of some of these variants may be lower in normal tissue than in tumor tissue, suggesting that the mechanisms generating ER variantmRNAs exist in normal breast tissue and may be deregulated in breast cancer tissues.
Early pregnancy in the ewe: effects of oestradiol and progesterone on uterine metabolism and on embryo survival.
- B. G. Miller, N. Moore, L. Murphy, G. Stone
- Biology, MedicineAustralian Journal of Biological Sciences
- 1 August 1977
The hormonal regulation of embryo development during early pregnancy in the ewe has been examined and embryos were transferred to the ewes on the 4th day after induced oestrus and killed at 6 or 13 days after transfer to assess embryo development.
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