• Publications
  • Influence
Evolution of competitive ability in Drosophila by density-dependent natural selection.
  • L. Mueller
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 June 1988
The theory of density-dependent natural selection predicts that populations kept at extreme densities should evolve different competitive abilities for limited resources. These predictions have been
Theoretical and Empirical Examination of Density-Dependent Selection
TLDR
A major transition from field-based observations and conjecture to carefully controlled laboratory selection experiments has permitted crucial tests of theories of density-dependent natural selection and a deeper understanding of the mechanisms of adaptation to different levels of population crowding.
Genetic variation and random drift in autotetraploid populations.
TLDR
The treatment suggests that the "gametic homozygosity" provides a unified approach for comparing genotypes within a population as well as comparing genetic variation between populations with different levels of ploidy.
Stability in Model Populations
A Genetic Polymorphism Maintained by Natural Selection in a Temporally Varying Environment
TLDR
It is shown that natural selection in environments that are crowded with larvae of the fruit fly can maintain a genetic polymorphism with one group of genotypes specializing on the early part of the environment and a second group specialize on the late part.
Trade-off between r-selection and K-selection in Drosophila populations.
  • L. Mueller, F. Ayala
  • Biology
    Proceedings of the National Academy of Sciences…
  • 1 February 1981
TLDR
Density-dependent genetic evolution was tested in experimental populations of Drosophila melanogaster subject for eight generations to natural selection under high (K-selection) or low (r- selection) population density regimes, and results corroborate the predictions derived from formal models of density-dependent selection.
Interactions between density-dependent and age-specific selection in Drosophila melanogaster
TLDR
A variety of laboratory populations of Drosophila melanogaster have been created to study the effects of density-dependent natural selection and age-specific natural selection on changes in life span and resistance to stresses.
DENSITY‐DEPENDENT NATURAL SELECTION IN DROSOPHILA: EVOLUTION OF GROWTH RATE AND BODY SIZE
TLDR
The results have important implications for understanding the evolution of body size in natural populations of Drosophila, and stand against some widespread beliefs that body size may represent a compromise between the conflicting effects of genetic variation in larval and adult performance.
Evolutionary theory predicts late-life mortality plateaus.
  • L. Mueller, M. Rose
  • Biology
    Proceedings of the National Academy of Sciences…
  • 24 December 1996
TLDR
Extensions to the evolutionary theory of aging are developed which indicate that such late-life mortality plateaus are to be expected when enough late- life data are collected, with both antagonistic pleiotropy and mutation accumulation as driving population genetic mechanisms.
How Repeatable is Adaptive Evolution? The Role of Geographical Origin and Founder Effects in Laboratory Adaptation
TLDR
The findings suggest that the initial laboratory evolution of weakly selected characters may be unpredictable, even when the key adaptations under evolutionary domestication are predictable with respect to their trajectories.
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