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Regional, cellular, and subcellular variations in the distribution of D1 and D5 dopamine receptors in primate brain
The anatomical segregation of the D1 and D5 receptors at the subcellular level in cerebral cortex and at the cellular level in subcortical areas suggest that these closely related receptors may be preferentially associated with different circuit elements and may play distinct regulatory roles in synaptic transmission. Expand
Localization of dopamine D4 receptors in GABAergic neurons of the primate brain
It is suggested that clozapine's beneficial effects in schizophrenia may be achieved, in part, through D4-mediated GABA modulation, possibly implicating disinhibition of excitatory transmission in intrinsic cortical, thalamocortical and extrapyramidal pathways. Expand
Prominence of the dopamine D2 short isoform in dopaminergic pathways.
The results show that the splice variants of the dopamine D2 receptor are differentially distributed and possess distinct functions, and the strategic localization of the D2 short isoform in dopaminergic cell bodies and axons strongly suggests that this isoform is the likely dopamine autoreceptor, whereas theD2 long isoforms is primarily a postsynaptic receptor. Expand
Dual signaling regulated by calcyon, a D1 dopamine receptor interacting protein.
A mechanism is delineated by which D1 receptors can shift effector coupling to stimulate robust intracellular calcium (Ca2+i) release as a result of interaction with calcyon, which should provide insight into the D1 receptor-modulated cognitive functions of prefrontal cortex. Expand
Prenatal development of GABA‐ergic neurons in the neocortex of the rat
The present study shows that in the prenatal rat neocortex the GABA immunoreactive neurons are not limited to the marginal, subplate, and intermediate zones, but are also found in all fetal zones ofExpand
Association of m1 and m2 muscarinic receptor proteins with asymmetric synapses in the primate cerebral cortex: morphological evidence for cholinergic modulation of excitatory neurotransmission.
The association of m1 and m2 receptors with asymmetric synapses in central pathways, which use exciteatory amino acids as neurotransmitters, provides a morphological basis for cholinergic modulation of excitatory neurotransmission. Expand
Muscarinic m1 and m2 receptor proteins in local circuit and projection neurons of the primate striatum: Anatomical evidence for cholinergic modulation of glutamatergic prefronto‐striatal pathways
The remarkable segregation of the m1 and m2 receptor proteins to projection and local circuit neurons suggests a functional segregation of m2 mediated cholinergic actions in the striatum: m1 receptors modulate extrinsic glutamatergic and monoaminergic afferents and intrinsic GABAergicafferents onto projection neurons, whereas m2 receptors regulate acetylcholine release from axons of cholinergy interneurons. Expand
Prenatal development of neurons in the human prefrontal cortex: I. A qualitative Golgi study
The axonal pattern of the subplate neurons suggests a possible functional role for them as either interneurons or projection neurons in the developing human prefrontal cortex from 10.5 to 40 weeks of gestation. Expand
Neuronal development in human prefrontal cortex in prenatal and postnatal stages.
This chapter discusses the neuronal development in human prefrontal cortex in prenatal and postnatal stages through six different periods on the basis of data on changes in cortical histogenetic events. Expand
Nucleus subputaminalis (ayala): the still disregarded magnocellular component of the basal forebrain may be human specific and connected with the cortical speech area
The location of subputaminal cholinergic neurons within the frontal lobe, the ascension of their fibers through the external capsule towards the inferior frontal gyrus, and the most protracted development among all magnocellular aggregations within the basal forebrain strongly suggest that they may be connected with the cortical speech area. Expand