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Requirement of the MRN complex for ATM activation by DNA damage
- T. Uziel, Y. Lerenthal, L. Moyal, Y. Andegeko, L. Mittelman, Y. Shiloh
- Biology, Medicine
- The EMBO journal
- 15 October 2003
The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches of… Expand
Enhanced phosphorylation of p53 by ATM in response to DNA damage.
The ATM protein, encoded by the gene responsible for the human genetic disorder ataxia telangiectasia (A-T), regulates several cellular responses to DNA breaks. ATM shares a phosphoinositide… Expand
The histone H2B-specific ubiquitin ligase RNF20/hBRE1 acts as a putative tumor suppressor through selective regulation of gene expression.
Histone monoubiquitylation is implicated in critical regulatory processes. We explored the roles of histone H2B ubiquitylation in human cells by reducing the expression of hBRE1/RNF20, the major… Expand
Requirement of ATM-dependent monoubiquitylation of histone H2B for timely repair of DNA double-strand breaks.
The cellular response to DNA double-strand breaks (DSBs) is mobilized by the protein kinase ATM, which phosphorylates key players in the DNA damage response (DDR) network. A major question is how ATM… Expand
Nuclear retention of ATM at sites of DNA double strand breaks.
- Y. Andegeko, L. Moyal, L. Mittelman, I. Tsarfaty, Y. Shiloh, G. Rotman
- Biology, Medicine
- The Journal of biological chemistry
- 12 October 2001
The ATM protein kinase mediates a rapid induction of cellular responses to DNA double strand breaks (DSBs). ATM kinase activity is enhanced immediately after exposure of cells to DSB-inducing agents,… Expand
miR‐155 is involved in tumor progression of mycosis fungoides
Biopsy specimens from 23 early stage and 19 tumor‐stage mycosis fungoides (MF) patients were evaluated for miR‐155 expression by real‐time qualitative PCR and compared with 15 biopsy specimens from… Expand
The histone H 2 B-specific ubiquitin ligase RNF 20 / hBRE 1 acts as a putative tumor suppressor through selective regulation of gene expression
Department of Molecular Cell Biology, The Weizmann Institute of Science, Rehovot 76100, Israel; Department of Molecular Genetics, The Weizmann Institute of Science, Rehovot 76100, Israel; Gene… Expand
Cancer-Associated Fibroblasts in Mycosis Fungoides Promote Tumor Cell Migration and Drug Resistance via CXCL12/CXCR4.
- Anna Aronovich, L. Moyal, +10 authors E. Hodak
- Chemistry, Medicine
- The Journal of investigative dermatology
- 11 August 2020
Cancer cells are known to reprogram normal fibroblasts into cancer-associated fibroblasts (CAFs) to act as tumor supporters. The presence and role of CAFs in mycosis fungoides (MF), the most common… Expand
RNF20–RNF40: A ubiquitin‐driven link between gene expression and the DNA damage response
The DNA damage response (DDR) is emerging as a vast signaling network that temporarily modulates numerous aspects of cellular metabolism in the face of DNA lesions, especially critical ones such as… Expand
ATM-dependent activation of the gene encoding MAP kinase phosphatase 5 by radiomimetic DNA damage
Cellular responses to DNA damage are mediated by an extensive network of signaling pathways. The ATM protein kinase is a master regulator of the response to double-strand breaks (DSBs), the most… Expand