• Publications
  • Influence
The Ctenophore Genome and the Evolutionary Origins of Neural Systems
The draft genome of Pleurobrachia bachei, Pacific sea gooseberry, together with ten other ctenophore transcriptomes, are presented, and show that they are remarkably distinct from other animal genomes in their content of neurogenic, immune and developmental genes. Expand
Acoelomorph flatworms are deuterostomes related to Xenoturbella
This phylogeny makes sense of the shared characteristics of Xenoturbellida and Acoelomorpha, and implies the loss of various deuterostome characters in the Xenobiology including coelomic cavities, through gut and gill slits. Expand
Phylogenomics reveals deep molluscan relationships
This work uses transcriptome and genome data from all major lineages (except Monoplacophora) and recovers a well-supported topology for Mollusca to propose the node-based name Pleistomolluscan, which strongly support the Aculifera hypothesis and finds support for advanced cephalization and shells as possibly having multiple origins within Mollsusca. Expand
Deuterostome phylogeny reveals monophyletic chordates and the new phylum Xenoturbellida
To study the relationships among all deuterostome groups, an alignment of more than 35,000 homologous amino acids is assembled, including new data from a hemichordate, starfish and Xenoturbella and it is concluded that chordates are monophyletic. Expand
Error, signal, and the placement of Ctenophora sister to all other animals
Investigating possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systemic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model finds a single, statistically robust placement of ctenophores as the authors' most distant animal relatives. Expand
Neuronal Transcriptome of Aplysia: Neuronal Compartments and Circuitry
This collection represents the largest database available for any member of the Lophotrochozoa and therefore provides additional insights into evolutionary strategies used by this highly successful diversified lineage, one of the three proposed superclades of bilateral animals. Expand
Simple cDNA normalization using kamchatka crab duplex-specific nuclease.
A novel simple cDNA normalization method that may be effectively used for samples enriched with full-length cDNA sequences and employed to normalize cDNA from nervous tissues of the marine mollusc Aplysia californica to illustrate further the efficiency of the normalization technique. Expand
On the Independent Origins of Complex Brains and Neurons
  • L. Moroz
  • Biology, Medicine
  • Brain, Behavior and Evolution
  • 1 December 2009
Injury-associated mechanisms leading to secretion of signal peptides can be considered as evolutionary predecessors of inter-neuronal signaling and the major factors in the appearance of neurons in the first place. Expand
PhyloTreePruner: A Phylogenetic Tree-Based Approach for Selection of Orthologous Sequences for Phylogenomics
PhyloTreePruner is a software utility that uses a phylogenetic approach to refine orthology inferences made using phenetic methods and takes into account support values on the tree and avoids unnecessarily deleting sequences in cases where a weakly supported tree topology incorrectly indicates paralogy. Expand
Alkalinization by chloride/bicarbonate pathway in larval mosquito midgut
Time-lapse video assays of pH profiles in vivo revealed that ingestion of the carbonic anhydrase inhibitor acetazolamide and the ion exchange inhibitor DIDS, at 10−4 M eliminates lumen alkalinization. Expand