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Degradation of Soluble Amyloid β-Peptides 1–40, 1–42, and the Dutch Variant 1–40Q by Insulin Degrading Enzyme from Alzheimer Disease and Control Brains
Insulin degrading enzyme (IDE) is a metalloprotease that has been involved in amyloid β peptide (Aβ) degradation in the brain. We analyzed the ability of human brain soluble fraction to degrade AβExpand
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Plaque-Associated Overexpression of Insulin-Degrading Enzyme in the Cerebral Cortex of Aged Transgenic Tg2576 Mice With Alzheimer Pathology
It was proposed that insulin-degrading enzyme (IDE) participates in the clearance of amyloid &bgr; (A&bgr;) in the brain, and its low expression or activity may be relevant for the progression ofExpand
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  • Open Access
Differential Degradation of Amyloid β Genetic Variants Associated with Hereditary Dementia or Stroke by Insulin-degrading Enzyme*
Inherited amino acid substitutions at position 21, 22, or 23 of amyloid β (Aβ) lead to presenile dementia or stroke. Insulin-degrading enzyme (IDE) can hydrolyze Aβ wild type, yet whether IDE isExpand
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Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease.
Adult neurons are generally accepted to be in a quiescent, nonproliferative state. However, it is becoming increasingly apparent that, in Alzheimer's disease (AD), alterations in cell cycleExpand
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Presenilin 1 Met146Leu variant due to an A&T transversion in an early‐onset familial Alzheimer's disease pedigree from Argentina
Most of the cases of early‐onset familial Alzheimer's disease (FAD) are related to missense mutations in the presenilin 1 (PS‐1) gene on chromosome 14. Although PS‐1 mutations are distributedExpand
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Transcriptional Regulation of Insulin-degrading Enzyme Modulates Mitochondrial Amyloid β (Aβ) Peptide Catabolism and Functionality*
Background: Mitochondrial accumulation of amyloid β (Aβ) promotes organelle dysfunction and Alzheimer disease (AD) neuropathology. Results: IDE-Met1 localizes in mitochondria, is present in brain,Expand
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Carbohydrates and Immunology: Synthetic Oligosaccharide Antigens for Vaccine Formulation
Despite the enormous progress achieved by modern medicine, numerous diseases still have a profound impact on public health. Infectious diseases caused by a variety of microorganisms (viruses, fungiExpand
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  • Open Access
Insulin-degrading Enzyme in Brain Microvessels
The accumulation of amyloid β (Aβ) in the walls of small vessels in the cerebral cortex is associated with diseases characterized by dementia or stroke. These include Alzheimer's disease, DownExpand
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  • Open Access
Detergent resistant membrane-associated IDE in brain tissue and cultured cells: Relevance to Aβ and insulin degradation
BackgroundInsulin degrading enzyme (IDE) is implicated in the regulation of amyloid β (Aβ) steady-state levels in the brain, and its deficient expression and/or activity may be a risk factor inExpand
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