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Identifying Signatures of Natural Selection in Tibetan and Andean Populations Using Dense Genome Scan Data
The results indicate that several key HIF-regulatory and targeted genes are responsible for adaptation to high altitude in Andeans and Tibetans, and several different chromosomal regions are implicated in the putative response to selection.
Consensus statement on chronic and subacute high altitude diseases.
- F. Léon-Velarde, M. Maggiorini, G. Zubieta-Calleja
- MedicineHigh altitude medicine & biology
- 1 August 2005
This is an international consensus statement of an ad hoc committee formed by the International Society for Mountain Medicine and represents the committee's interpretation of the current knowledge with regard to the most common chronic and subacute high altitude diseases.
Temporal relationships between hormonal and hemodynamic changes in early human pregnancy.
Peripheral vasodilation occurs early in pregnancy prior to full placentation in association with renal vasodilated and activation of the renin-angiotensin-aldosterone system, suggesting that ANP increases in response to changes in intravasular volume.
Human adaptation to high altitude: regional and life-cycle perspectives.
Tibetans have several physiological distinctions that confer adaptive benefit consistent with their probable greater generational length of high-altitude residence, and several of the distinctions demonstrated by Tibetans parallel the differences between natives and newcomers, suggesting that the degree of protection or adaptive benefit relative to newcomers is enhanced for the Tibetans.
Maternal Uterine Vascular Remodeling During Pregnancy
This review summarizes what is currently known about the time course and extent of the remodeling process, and how local vs. systemic factors influence its genesis, and focuses on upstream maternal vessels rather than spiral artery changes.
Mitochondrial DNA analysis in Tibet: implications for the origin of the Tibetan population and its adaptation to high altitude.
It is suggested that mtDNA mutations are unlikely to play a major role in the adaptation of Tibetans to high altitudes and is supportive of previous genetic evidence that Tibetans, although located in southern Asia, share common ancestral origins with northern Mongoloid populations.
Slower fatigue and faster recovery of the adductor pollicis muscle in women matched for strength with men.
The findings are consistent with the hypothesis that slower adductor pollicis muscle fatigue in women is linked with differences between men and women both in impairment of force generating capacity, per se, and in rates of recovery between contractions.
Human genetic adaptation to high altitude.
- L. Moore
- BiologyHigh altitude medicine & biology
Recent studies which address the question as to whether genetic adaptation to high altitude has occurred and suggest that Tibetans are better adapted are reviewed.
A genomewide admixture mapping panel for Hispanic/Latino populations.
This report reports a genomewide AM panel with 2,120 AIMs showing high frequency differences between Native American and European populations, which will make it possible to apply AM approaches in many admixed populations throughout the Americas.
Identifying positive selection candidate loci for high-altitude adaptation in Andean populations
A study to identify selection-nominated candidate genes involved in adaptation to hypoxia in one highland group, Andeans from the South American Altiplano, and results from particular HIF-targeted genes suggest that genes in this pathway could play a role in Andean adaptation to high altitude, even if the pathway as a whole does not show higher relative rates of evolution.