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Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).
From these studies it is concluded that this virus as well as the previous HTLV isolates belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in humans and may be involved in several pathological syndromes, including AIDS.
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS). 1983.
- F. Barré-Sinoussi, J. Chermann, L. Montagnier
- Medicine, BiologyRevista de investigacion clinica; organo del…
- 1 March 2004
It is concluded that this virus as the previous HTVL isolate belong to a general family of T-lymphotropic retroviruses that are horizontally transmitted in human and may be involved in several pathological syndromes, including AIDS.
T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV
Preincubation of T4+ lymphocytes with three individual monoclonal antibodies directed at the T4 glycoprotein blocked cell infection by LAV, strongly support the view that a surface molecule directly involved in cellular functions acts as, or is related to, the receptor for a human retrovirus.
HIV-1 Genome Nuclear Import Is Mediated by a Central DNA Flap
Changes in growth properties on passage in tissue culture of viruses derived from infectious molecular clones of HIV-1LAI, HIV-1MAL, and HIV-1ELI.
Simian Immunodeficiency Virus Replicates to High Levels in Sooty Mangabeys without Inducing Disease
The data indicated that SIVsmFr replicated at a high rate in mangabeys, despite the nonpathogenic character of infection in this host, and the lack of pathogenicity of Sivsm for its natural host cannot be explained by limited viral replication or by tight containment of viral production.
Genetic variability of the AIDS virus: Nucleotide sequence analysis of two isolates from African patients
The discovery of HIV as the cause of AIDS.
This search for retroviruses in human cancers particularly breast cancers and leukemias finally paid off with the discovery of human T-cell leukemia virus types 1 and 2 the first of which was shown to cause an unusual T- cell leukemia.
Human immunodeficiency virus type 2 infection associated with AIDS in West Africa.
Evidence of infection with HIV-2 in 30 patients, almost all from West Africa, indicates that some cases of AIDS in West Africa may be caused by HIV-1, but the extent of the spread of this virus and its clinical correlates will require careful epidemiologic investigation.