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Lucifensin, the long-sought antimicrobial factor of medicinal maggots of the blowfly Lucilia sericata
TLDR
It is believed that lucifensin is that long-sought larger molecular weight antimicrobial factor of the Lucilia sericata excretions/secretions believed to be effective against pathogenic elements of the wound microbial flora. Expand
Toxicity study of antimicrobial peptides from wild bee venom and their analogs toward mammalian normal and cancer cells
Recently, we have isolated and characterized remarkable antimicrobial peptides (AMPs) from the venom reservoirs of wild bees. These peptides (melectin, lasioglossins, halictines and macropin) andExpand
Lucifensin, a Novel Insect Defensin of Medicinal Maggots: Synthesis and Structural Study
TLDR
The total chemical synthesis of this peptide of 40 amino acid residues and three intramolecular disulfide bridges by using three different protocols yielded a peptide with a pattern of disulfides bridges identical to that of native lucifensin. Expand
Lasiocepsin, a novel cyclic antimicrobial peptide from the venom of eusocial bee Lasioglossum laticeps (Hymenoptera: Halictidae)
TLDR
The synthetic lasiocepsin possessed antimicrobial activity against both Gram-positive and -negative bacteria, antifungal activity against Candida albicans, and no hemolytic activity against human erythrocytes. Expand
Shared CaM‐ and S100A1‐binding epitopes in the distal TRPM4 N terminus
TLDR
The molecular models supported by data from the fluorescence method confirmed that the complexes formations are mediated by the positively charged and hydrophobic residues present at the TRPM4 N terminus‐binding epitopes, suggesting that the molecular complexes of TR PM4/CaM and TRPM 4/S100A1 would lead to the modulation of the channel functions. Expand
How proteases from Enterococcus faecalis contribute to its resistance to short &agr;‐helical antimicrobial peptides
TLDR
It was found that HYL‐20 was primarily deamidated at its C‐terminal which made the peptide susceptible to consecutive intramolecular cleavage by GelE, which resulted in increased antimicrobial activity against E. faecalis. Expand
Novel antimicrobial peptides from the venom of the eusocial bee Halictus sexcinctus (Hymenoptera: Halictidae) and their analogs
TLDR
Improvement in HAL-1 and HAL-2 analogs basically relates to the increase of antimicrobial activity against pathogenic Pseudomonas aeruginosa and to the mitigation of hemolytic activity. Expand
Effect of hydrocarbon stapling on the properties of α-helical antimicrobial peptides isolated from the venom of hymenoptera
TLDR
The CD spectra of the singly stapled peptides measured in water showed only a slightly better propensity to form α-helical structure when compared to native peptides, whereas the doubly Stapled analogs exhibited dramatically enhanced α-helicity. Expand
Discovery of 6-Diazo-5-oxo-l-norleucine (DON) Prodrugs with Enhanced CSF Delivery in Monkeys: A Potential Treatment for Glioblastoma.
TLDR
It is demonstrated that DON inhibits glutamine metabolism and provides antitumor efficacy in a murine model of glioblastoma, although toxicity was observed. Expand
Discovery of a para-Acetoxy-benzyl Ester Prodrug of a Hydroxamate-Based Glutamate Carboxypeptidase II Inhibitor as Oral Therapy for Neuropathic Pain.
TLDR
Para-acetoxybenzyl-based prodrugs with additional ester promoiety(ies) on carboxylate(s) were examined for their ability to deliver 1 to plasma and isopropyloxycarbonyloxymethyl (POC) ester 30 was the only prodrug that achieved substantial plasma levels of 1. Expand
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