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Comparison of the metabolism of 2,4-toluenediamine in rats and mice.
The excretion, distribution, and metabolism of 2,4-toluenediamine (TDA) have been compared in rats and mice. The elimination of TDA metabolites into urine was faster and more complete in mice than inExpand
Identification of new water-soluble metabolites of acetanilide.
Two new urinary metabolites of acetanilide in rats were shown to be the mer-capturic acid derivatives3-[(5-acetamido-2-hydroxyphenyl)thio]-N-acetylalanine and 3-[5- acetamidophenyl)Thio]-n-acetelalanine, which may involve an intermediate expoxide. Expand
Metabolism of N-2-fluorenylacetamide in X/Gf mice: lack of correlation between biochemical interaction and carcinogenicity.
A comparative study of the metabolism of the carcinogen N-2-fluorenylacetamide by mice of the X/Gf strain and the NiH Swiss strain showed slight but not outstanding differences in metabolic patterns. Expand
Mechanisms of the inhibitory action of p-hydroxyacetanilide on carcinogenesis by N-2-fluorenylacetamide or N-hydroxy-N-2-fluorenylacetamide.
The protective effect of p- OH-AA against liver tumor induction with FAA or N-OH-FAA may in part result from a combination of the decreased binding of carcinogen to hepatic cellular macromolecules and the increased excretion as the glucuronide conjugates. Expand
The metabolism of 6-aminochrysene in the rat.
Abstract The absorption, distribution and excretion of 6 -aminochrysene- 5 , 6 - 14 C were investigated in rats. The highest concentration of radioactivity in the organs at 48 hr after an i. p. doseExpand
Alteration of the metabolism of the carcinogen N-2-fluorenylacetamide by acetanilide
Abstract In order to elucidate the mechanisms underlying the reduction of the toxicity and carcinogenicity of N -2-fluorenylacetamide by the simultaneous administration of acetanilide, the fate ofExpand
Changes in the metabolism of labelled acetanilide and binding of isotope to serum and liver macromolecules during chronic administration.
4-Hydroxyacetanilide, the major metabolite, was found free, as well as conjugated with glucuronic and sulphuric acids in all groups, and binding to DNA, RNA and proteins of liver at 4 weeks was 180-, 15- and 33-fold greater, respectively, than the values found ... Expand