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Toxicities of 48 pharmaceuticals and their freshwater and marine environmental assessment in northwestern France

Results showed that no immediate acute toxicities were expected even if some compounds displayed strong toxicities at very low concentrations, and Antibiotics, antidepressants, and antifungals would deserve attention because of their high or median ecological risk suspected on marine and freshwater ecosystems.
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Transgenerational effects of two antidepressants (sertraline and venlafaxine) on Daphnia magna life history traits.

The transgenerational effects of sertraline and venlafaxine on the life traits of Daphnia magna over two generations under environmentally realistic concentrations point out the need to perform multigeneration tests to assess the environmental risk of pharmaceuticals in nontarget organisms.
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Comparison of the sensitivity of seven marine and freshwater bioassays as regards antidepressant toxicity assessment

Algae and the embryo–larval stages of the oyster C. gigas were the most sensitive taxa, and the marine crustacean A. salina was the least sensitive species, highlighting the importance of using a test battery.
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Acute toxicity of 8 antidepressants: what are their modes of action?

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The integrated biomarker response revisited: optimization to avoid misuse

A new calculation method is proposed based on both a more simple formula and a permutation procedure that should rightly avoid the misuse and bias that were recorded in the integrated biomarker response (IBR).
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Assessment of the health status of Donax trunculus from the Gulf of Tunis using integrative biomarker indices

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Early defense responses in the freshwater bivalve Corbicula fluminea exposed to copper and cadmium: Transcriptional and histochemical studies

Results showed that lysosomal system, neutral lipids content, and mRNA levels were modified, suggesting their early response against oxidative stress and their important role in cell integrity, as efficient biomarkers of metal contamination in the aquatic environment.
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Interactions between parasitism and biological responses in zebra mussels (Dreissena polymorpha): Importance in ecotoxicological studies.

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Assessment of cytotoxic and immunomodulatory properties of four antidepressants on primary cultures of abalone hemocytes (Haliotis tuberculata).

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Towards a better understanding of biomarker response in field survey: a case study in eight populations of zebra mussels.

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