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International union of pharmacology. XXII. Nomenclature for chemokine receptors.
TLDR
A widely accepted receptor nomenclature system is described, ratified by the International Union of Pharmacology, that is facilitating clear communication in this area and updating current concepts of the biology and pharmacology of the chemokine system. Expand
The pathogenic basis of malaria
TLDR
Insight into the complexity of malaria pathogenesis is vital for understanding the disease and will provide a major step towards controlling it. Expand
Switches in expression of plasmodium falciparum var genes correlate with changes in antigenic and cytoadherent phenotypes of infected erythrocytes
TLDR
It is shown that expression of variant antigenic determinants is correlated with expression of individual members of a large, multigene family named var, which is consistent with the involvement of var genes in antigenic variation and binding to endothelium. Expand
A family of erythrocyte binding proteins of malaria parasites.
TLDR
It is proposed that the Duffy binding proteins and the sialic acid binding protein are members of a gene family, separated in evolution, that may indicate the regions where the adhesin function resides. Expand
The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy.
TLDR
It is concluded that Duffy determinants (Fya or Fyb or both) on the erythrocyte surface are required for invasion of ery Throcytes by vivax merozoites. Expand
Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum.
TLDR
The domain of EBA-175 that binds erythrocytes was identified as region II with the use of truncated portions of E BA-175 expressed on COS cells, and the identification of both the receptor and ligand domains may suggest rational designs for receptor blockade and vaccines. Expand
Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion
TLDR
The binding domains of these malaria ligands represent potential vaccine candidates and targets for receptor-blockade therapy and indicate conservation of the domain for erythrocyte binding in evolutionarily distant malaria species. Expand
Binding of Plasmodium merozoite proteins RON2 and AMA1 triggers commitment to invasion
TLDR
Results identify the binding of RON2 to the hydrophobic pocket of AMA1 as the step that commits Plasmodium merozoites to RBC invasion and point to RON 2 as a potential vaccine candidate. Expand
Classification of adhesive domains in the Plasmodium falciparum erythrocyte membrane protein 1 family.
TLDR
The sequence classification of DBL and CIDR types may have predictive value for identifying PfEMP1 domains with a particular binding property, and this information might be used to develop interventions targeting parasite binding variants that cause disease. Expand
Genetic selection of a Plasmodium-refractory strain of the malaria vector Anopheles gambiae.
TLDR
Production of fully refractory and fully susceptible mosquito strains was achieved through a short series of selective breeding steps, indicating a relatively simple genetic basis for refractoriness and encourages consideration of genetic manipulation of natural vector populations as a malaria control strategy. Expand
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