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The Role of the Transcription Factor CREB in Immune Function
Current advances involving CREB in immune function are summarized and phosphorylated CREB has been proposed to directly inhibit NF-κB activation by blocking the binding of CREB binding protein to the NF-σκB complex, thereby limiting proinflammatory responses. Expand
IL-17 is essential for host defense against cutaneous Staphylococcus aureus infection in mice.
This study defines what it believes to be a novel role for IL-17-producing epidermal gammadelta T cells in innate immunity against S. aureus cutaneous infection. Expand
MyD88 mediates neutrophil recruitment initiated by IL-1R but not TLR2 activation in immunity against Staphylococcus aureus.
It is found that lesions of S. aureus-infected MyD88- and IL-1R-deficient mice were substantially larger with higher bacterial counts compared with wild-type mice, suggesting that resident skin cells utilize IL- 1R/MyD88 signaling to promote neutrophil recruitment. Expand
A Critical Role for Hemolysins and Bacterial Lipoproteins in Staphylococcus aureus-Induced Activation of the Nlrp3 Inflammasome1
It is shown that the ability of Staphylococcus aureus to activate caspase-1 and induce IL-1β secretion resides in culture supernatants of growing bacteria, and that hemolysins promote in the presence of lipoproteins the activation of the Nlrp3 inflammasome. Expand
Toll-like receptors in skin.
  • L. Miller
  • Biology, Medicine
  • Advances in dermatology
  • 1 November 2008
Future research involving TLR-based therapies for skin diseases, skin cancer, and infections will hopefully provide new insights into host defense against skin pathogens and novel therapeutic targets aimed at treating skin disease and skin cancer. Expand
Immunity against Staphylococcus aureus cutaneous infections
Recent discoveries have identified a key role for interleukin-1 (IL-1)- and IL-17-mediated immune responses in promoting neutrophil recruitment to the site of infection in the skin, a process that is required for host defence and bacterial clearance. Expand
Neutrophil-derived IL-1β Is Sufficient for Abscess Formation in Immunity against Staphylococcus aureus in Mice
IL-1β and neutrophil abscess formation during an infection are functionally, temporally and spatially linked as a consequence of direct IL-1 β production by neutrophils. Expand
Toll-like receptors in the skin
There have been an increasing number of reports demonstrating that TLRs play a key role in cutaneous host defense mechanisms against bacterial, fungal, and viral pathogens. Expand
IL-23 and IL-17A, but Not IL-12 and IL-22, Are Required for Optimal Skin Host Defense against Candida albicans
Exogenous recombinant IL-17A injected at the site of skin infection promoted more rapid healing of candidiasis in both wild-type mice and mice deficient in IL-23 and IL-12, and may serve as a potential therapy to enhance healing in individuals with chronic cutaneous candidiasis. Expand
Inflammasome-Mediated Production of IL-1β Is Required for Neutrophil Recruitment against Staphylococcus aureus In Vivo1
Mice deficient in the inflammasome component apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) had the same defects in neutrophil recruitment and host defense as IL-1β-deficient mice, demonstrating an essential role for the infammasome in mediating the production of active IL- 1β to promote neutrophIL recruitment in host defense against S. aureus. Expand