Transcriptional regulation of metabolism.
- B. Desvergne, L. Michalik, W. Wahli
- BiologyPhysiological Reviews
- 1 April 2006
This review reviews data on the transcriptional regulation of the intermediary metabolism, i.e., glucose, amino acid, lipid, and cholesterol metabolism and discusses how transcription factors integrate signals from various pathways to ensure homeostasis.
International Union of Pharmacology. LXI. Peroxisome Proliferator-Activated Receptors
- L. Michalik, J. Auwerx, W. Wahli
- BiologyPharmacological Reviews
- 1 December 2006
The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology…
From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.
- J. Feige, L. Gelman, L. Michalik, B. Desvergne, W. Wahli
- BiologyProgress in lipid research
- 1 March 2006
Peroxisome-proliferator-activated receptors and cancers: complex stories
- L. Michalik, B. Desvergne, W. Wahli
- Biology, MedicineNature Reviews. Cancer
- 2004
Peroxisome-proliferator-activated receptors (PPARs) are nuclear hormone receptors that mediate the effects of fatty acids and their derivatives at the transcriptional level. Through these pathways,…
Antiapoptotic role of PPARbeta in keratinocytes via transcriptional control of the Akt1 signaling pathway.
- N. Di-Poï, N. Tan, L. Michalik, W. Wahli, B. Desvergne
- BiologyMolecules and Cells
- 1 October 2002
PPARs at the crossroads of lipid signaling and inflammation
- W. Wahli, L. Michalik
- BiologyTrends in endocrinology and metabolism
- 1 July 2012
Reciprocal regulation of brain and muscle Arnt-like protein 1 and peroxisome proliferator-activated receptor alpha defines a novel positive feedback loop in the rodent liver circadian clock.
- L. Canaple, Juliette Rambaud, V. Laudet
- BiologyMolecular Endocrinology
- 1 August 2006
It is demonstrated that PPARalpha plays a specific role in the peripheral circadian control because it is required to maintain the circadian rhythm of the master clock gene brain and muscle Arnt-like protein 1 (bmal1) in vivo and fenofibrate induces calendar rhythm of clock gene expression in cell culture and up-regulates hepatic bmal1 in vivo.
Critical roles of PPAR beta/delta in keratinocyte response to inflammation.
- N. Tan, L. Michalik, W. Wahli
- BiologyGenes & Development
- 2001
It is shown, by use of cultures of primary keratinocytes from wild-type and PPAR beta/delta(-/-) mice, that such signals including TNF-alpha and IFN-gamma, induce keratinocyte differentiation.
PPARs: transcriptional effectors of fatty acids and their derivatives
- A. Hihi, L. Michalik, W. Wahli
- BiologyCellular and Molecular Life Sciences (CMLS)
- 1 May 2002
How fatty acids affect PPAR functions in the cell is discussed and possible cross-talk between the PPAR pathway and different endocrine routes within the cell, including the thyroid hormone and retinoid pathways are presented.
Rat PPARs: Quantitative Analysis in Adult Rat Tissues and Regulation in Fasting and Refeeding.
- P. Escher, O. Braissant, S. Basu-Modak, L. Michalik, W. Wahli, B. Desvergne
- Biology, MedicineEndocrinology
- 1 October 2001
Fasting can strongly influence PPAR expression, but in only a few selected tissues, including liver, kidney, heart, diaphragm, and esophagus.
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