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Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes
TLDR
Protective roles for H3K9me3 and Suv39h1 against the preactivated state of diabetic VSMC are demonstrated and dysregulation of epigenetic histone modifications may be a major underlying mechanism for metabolic memory and sustained proinflammatory phenotype of diabetic cells. Expand
Deficient 17β-Hydroxysteroid Dehydrogenase Type 2 Expression in Endometriosis: Failure to Metabolize 17β-Estradiol
TLDR
It follows that the product of the aromatase reaction, namely estrone, that is weakly estrogenic can be converted to the potent estrogen, 17β-estradiol, in endometriotic tissues. Expand
Tumor necrosis factor alpha and interleukin 11 secreted by malignant breast epithelial cells inhibit adipocyte differentiation by selectively down-regulating CCAAT/enhancer binding protein alpha and
TLDR
Desmoplastic reaction primarily occurs via the action of cytokines secreted by the malignant epithelial cells to inhibit differentiation of adipose fibroblasts to mature adipocytes. Expand
The Role of BRCA Status on the Prognosis of Patients with Epithelial Ovarian Cancer: A Systematic Review of the Literature with a Meta-Analysis
TLDR
Patients with BRCA dysfunction status tend to have a better outcome, but further prospective clinical studies comparing the different BRCa statuses in EOC is urgently needed to specifically define the most effective treatment for the separate patient groups. Expand
Deficient 17beta-hydroxysteroid dehydrogenase type 2 expression in endometriosis: failure to metabolize 17beta-estradiol.
TLDR
Inactivation of 17 beta-estradiol is impaired in endometriotic tissues due to deficient expression of 17betaHSD-2, which is normally expressed in eutopic endometrium in response to progesterone. Expand
RNA interference against HPV16 E7 oncogene leads to viral E6 and E7 suppression in cervical cancer cells and apoptosis via upregulation of Rb and p53
TLDR
It is demonstrated that 16E7-shRNA can induce simultaneous E6 and E7 suppression and lead to striking apoptosis in HPV16-related cancer cells by activating cellular p53, p21 and Rb and RNAi using E7 shRNA may have the gene-specific therapy potential for HPV 16-related cancers. Expand
Activation of fibronectin/PI-3K/Akt2 leads to chemoresistance to docetaxel by regulating survivin protein expression in ovarian and breast cancer cells.
TLDR
The results indicate that the activation of Akt2, promoted by FN attachment, might be critical in determining whether cells survive or undergo apoptosis, and targeting the PI-3K/Akt2 pathway might be a promising strategy for enhancing sensitivity to docetaxel in breast or ovarian cancer. Expand
Enhanced Proatherogenic Responses in Macrophages and Vascular Smooth Muscle Cells Derived From Diabetic db/db Mice
TLDR
It is demonstrated that monocyte/macrophages and VSMCs derived from db/db mice display a “preactivated” and proinflammatory phenotype associated with the pathogenesis of diabetic vascular dysfunction and atherosclerosis. Expand
Overexpression of vimentin contributes to prostate cancer invasion and metastasis via src regulation.
TLDR
Vimentin promotes tumor cell invasiveness and the targeting of vimentin/C-src may be a promising strategy for preventing or blocking prostate cancer metastasis. Expand
Elaiophylin, a novel autophagy inhibitor, exerts antitumor activity as a single agent in ovarian cancer cells
TLDR
It is demonstrated, for the first time, that elaiophylin is a novel autophagy inhibitor, with significant antitumor efficacy as a single agent or in combination in human ovarian cancer cells, establishing the potential treatment of ovarian cancer by this compound. Expand
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