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- Publications
- Influence
ADAMTS-13 rapidly cleaves newly secreted ultralarge von Willebrand factor multimers on the endothelial surface under flowing conditions.
Thrombotic thrombocytopenic purpura (TTP) is a devastating thrombotic disorder caused by widespread microvascular thrombi composed of platelets and von Willebrand factor (VWF). The disorder is… Expand
Platelets and shear stress.
- M. Kroll, J. Hellums, L. Mcintire, A. Schafer, J. Moake
- Medicine
- Blood
- 1996
C LINICAL BLEEDING or thrombosis results from a disturbance in the balance between a complex network of procoagulant and anticoagulant factors. This network involves three primary interactions, first… Expand
Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)
- D. Simon, Z. Chen, +8 authors J. López
- Biology, Medicine
- The Journal of experimental medicine
- 17 July 2000
The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are both dependent on the interaction of the leukocyte integrin, Mac-1, and a heretofore unknown platelet… Expand
The Glycoprotein Ib-IX-V Complex Is a Platelet Counterreceptor for P-Selectin
- G. Romo, J. Dong, +6 authors J. López
- Chemistry, Medicine
- The Journal of experimental medicine
- 20 September 1999
We have identified platelet glycoprotein (GP) Ibα as a counterreceptor for P-selectin. GP Ibα is a component of the GP Ib-IX-V complex, which mediates platelet adhesion to subendothelium at sites of… Expand
DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells
- S. McCormick, S. G. Eskin, +4 authors K. Chittur
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 31 July 2001
Using DNA microarray screening (GeneFilter 211, Research Genetics, Huntsville, AL) of mRNA from primary human umbilical vein endothelial cells (HUVEC), we identified 52 genes with significantly… Expand
Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1.
- E. Hentzen, S. Neelamegham, +4 authors S. Simon
- Chemistry, Medicine
- Blood
- 1 February 2000
TLDR
Platelet glycoprotein Ibalpha forms catch bonds with human WT vWF but not with type 2B von Willebrand disease vWF.
- T. Yago, Jizhong Lou, +9 authors C. Zhu
- Chemistry, Medicine
- The Journal of clinical investigation
- 2 September 2008
Arterial blood flow enhances glycoprotein Ibalpha (GPIbalpha) binding to vWF, which initiates platelet adhesion to injured vessels. Mutations in the vWF A1 domain that cause type 2B von Willebrand… Expand
Automated Selection of DAB-labeled Tissue for Immunohistochemical Quantification
- E. Brey, Z. Lalani, +4 authors C. Patrick
- Medicine
- The journal of histochemistry and cytochemistry…
- 1 May 2003
The increased use of immunohistochemistry (IHC) in both clinical and basic research settings has led to the development of techniques for acquiring quantitative information from immunostains.… Expand
Shear stress induced stimulation of mammalian cell metabolism
- J. Frangos, L. Mcintire, S. G. Eskin
- Biology, Medicine
- Biotechnology and bioengineering
- 5 October 1988
A flow apparatus has been developed for the study of the metabolic response of anchorage‐dependent cells to a wide range of steady and pulsatile shear stresses under well‐controlled conditions. Human… Expand
E-selectin supports neutrophil rolling in vitro under conditions of flow.
- O. Abbassi, T. Kishimoto, L. Mcintire, D. C. Anderson, C. Smith
- Biology, Medicine
- The Journal of clinical investigation
- 1 December 1993
E-selectin was evaluated for its ability to support neutrophil adhesion under conditions of flow. At a wall shear stress of 1.85 dyn/cm2, neutrophils were found to attach to E-selectin expressed on… Expand