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Triclosan targets lipid synthesis
TLDR
It is shown that triclosan blocks lipid synthesis in Escherichia coli, and that mutations in, or overexpression of, the gene fabI (which encodes enoyl reductase, involved in fatty acid synthesis) prevents this blockage. Expand
Overexpression of marA, soxS, or acrAB produces resistance to triclosan in laboratory and clinical strains of Escherichia coli.
TLDR
It is reported here that overexpression of the multidrug efflux pump locus acrAB, or of marA or soxS, both encoding positive regulators of acr AB, decreased susceptibility to triclosan 2-fold. Expand
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coli
TLDR
The findings suggest that the marA locus directly or indirectly increases micF expression, causing a posttranscriptional decrease in ompF mRNA and reduced amounts of OmpF. Expand
Genetic Evidence that InhA of Mycobacterium smegmatis Is a Target for Triclosan
TLDR
Results suggest that M. smegmatis InhA, like its Escherichia coli homolog FabI, is a target for triclosan. Expand
Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes
TLDR
It is suggested that marA-dependent fluoroquinolone resistance is linked to decreased cell permeability, only part of which can be accounted for by the reduction in OmpF. Expand
Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci
TLDR
Mutants of Escherichia coli selected for resistance to the disinfectant pine oil or to a household product containing pine oil also showed resistance to multiple antibiotics and overexpressed the marA gene, which increased the susceptibility of wild-type and mutant strains to pine oil. Expand
Ineffectiveness of Topoisomerase Mutations in Mediating Clinically Significant Fluoroquinolone Resistance inEscherichia coli in the Absence of the AcrAB Efflux Pump
TLDR
These studies indicate that, in the absence of the AcrAB pump, gyrase mutations fail to produce clinically relevant levels of fluoroquinolone resistance. Expand
The Clostridium perfringens Tet P determinant comprises two overlapping genes: tetA(P), which mediates active tetracycline efflux, and tetB(P), which is related to the ribosomal protection family of
TLDR
The complete nucleotide sequence and mechanism of action of the tetracycline‐resistance determinant Tet P, from Clostridium perfringens has been determined and it is proposed that tetB(P) evolved from the conjugative transfer into C. perfrings of a fer (M)‐like gene from another bacterium. Expand
Active efflux of tetracycline encoded by four genetically different tetracycline resistance determinants in Escherichia coli.
TLDR
Results demonstrate that active export of tetracycline is a common component of the mechanism for tetrACYcline resistance encoded by different plasmid-borne determinants in bacteria. Expand
Endogenous active efflux of norfloxacin in susceptible Escherichia coli
TLDR
It is suggested that in the OmpF mutant decreased outer membrane permeability, combined with active efflux across the inner membrane, in some manner results in decreased steady-state uptake of norfloxacin and lowered drug susceptibility. Expand
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