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Selective CCR2‐targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis
The CCL2/CCR2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and T cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. TheExpand
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Analysis and interpretation of infrared microscopic maps: Visualization and classification of skin components by digital staining and multivariate analysis
Four analytical methods have been applied to infrared microscopic maps of human skin which contained basal cell carcinoma tumors—namely, point spectroscopy, grayscale functional group mapping,Expand
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Ex Vivo Vibrational Spectroscopy Imaging
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Cy5.5-DTPA-galactosyl-dextran: a fluorescent probe for in vivo measurement of receptor biochemistry.
The high sensitivity of fluorescent reporters offers an opportunity to analytically probe the biochemistry of in vivo receptor systems with low target tissue concentration. We investigated theExpand
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LDA-Guided Search Engine for the Nonsubjective Analysis of Infrared Microscopic Maps
Acquisition of large data sets from human tissues by infrared (IR) microscopy is now routine. However, processing such large data sets, which may contain more than 10 000 spectra, provides anExpand
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Genome‐wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses
Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recentlyExpand
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Near-infrared spectroscopy for dermatological applications
The clinical diagnosis of many dermatological conditions suffers from inadequacies and a histopathological analysis of skin biopsies remains the standard for confirmation of a diagnosis. We suggestExpand
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Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit.
First generation chemokine ligand-Shiga A1 (SA1) fusion proteins (leukocyte population modulators, LPMs) were previously only obtained in small quantities due to the ribosomal inactivating proteinExpand
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Examining compassion and resilience through various lenses.
In the aftermath of the Mid-Staffs Enquiry, as part of our midwifery students' enquiry-based learning curriculum, a session was devised with the aim of enabling the students to harness the energy forExpand
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Anti-inflammatory approaches that target the chemokine network.
Chemokine-ligand/receptor axes play pivotal roles in a myriad of inflammatory, allergic and autoimmune diseases, as well as in the promotion of tumor growth and metastasis. Upon insult, tissueExpand
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