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Selective CCR2‐targeted macrophage depletion ameliorates experimental mesangioproliferative glomerulonephritis
- L. McIntosh, J. L. Barnes, V. L. Barnes, J. Mcdonald
- Medicine, Biology
- Clinical and experimental immunology
- 1 February 2009
The CCL2/CCR2 chemokine/receptor axis directs the chemotaxis of infiltrating monocytes/macrophages and T cells and plays a pivotal role in tissue damage and fibrosis in kidney diseases. The… Expand
Analysis and interpretation of infrared microscopic maps: Visualization and classification of skin components by digital staining and multivariate analysis
Four analytical methods have been applied to infrared microscopic maps of human skin which contained basal cell carcinoma tumors—namely, point spectroscopy, grayscale functional group mapping,… Expand
Cy5.5-DTPA-galactosyl-dextran: a fluorescent probe for in vivo measurement of receptor biochemistry.
- D. Vera, D. J. Hall, C. Hoh, Pascal Gallant, L. McIntosh, R. Mattrey
- Chemistry, Medicine
- Nuclear medicine and biology
- 1 October 2005
The high sensitivity of fluorescent reporters offers an opportunity to analytically probe the biochemistry of in vivo receptor systems with low target tissue concentration. We investigated the… Expand
LDA-Guided Search Engine for the Nonsubjective Analysis of Infrared Microscopic Maps
Acquisition of large data sets from human tissues by infrared (IR) microscopy is now routine. However, processing such large data sets, which may contain more than 10 000 spectra, provides an… Expand
Genome‐wide linkage analysis of 1,233 prostate cancer pedigrees from the International Consortium for prostate cancer Genetics using novel sumLINK and sumLOD analyses
Prostate cancer (PC) is generally believed to have a strong inherited component, but the search for susceptibility genes has been hindered by the effects of genetic heterogeneity. The recently… Expand
Near-infrared spectroscopy for dermatological applications
- L. McIntosh, Michael Jackson, H. Mantsch, J. Mansfield, A. N. Crowson, J. Toole
- 28 February 2002
The clinical diagnosis of many dermatological conditions suffers from inadequacies and a histopathological analysis of skin biopsies remains the standard for confirmation of a diagnosis. We suggest… Expand
Clinical grade production and characterization of a fusion protein comprised of the chemokine CCL2-ligand genetically fused to a mutated and truncated form of the Shiga A1 subunit.
- H. Su, M. Jack, +4 authors J. Mcdonald
- Medicine, Biology
- Protein expression and purification
- 1 August 2009
First generation chemokine ligand-Shiga A1 (SA1) fusion proteins (leukocyte population modulators, LPMs) were previously only obtained in small quantities due to the ribosomal inactivating protein… Expand
Examining compassion and resilience through various lenses.
- M. Nolan, F. Oliver, L. McIntosh, Jodie Y S Lee
- Medicine, Psychology
- The practising midwife
- 1 September 2014
In the aftermath of the Mid-Staffs Enquiry, as part of our midwifery students' enquiry-based learning curriculum, a session was devised with the aim of enabling the students to harness the energy for… Expand
Anti-inflammatory approaches that target the chemokine network.
- J. Mcdonald, B. Finck, L. McIntosh, S. Wilson
- Biology, Medicine
- Recent patents on inflammation & allergy drug…
Chemokine-ligand/receptor axes play pivotal roles in a myriad of inflammatory, allergic and autoimmune diseases, as well as in the promotion of tumor growth and metastasis. Upon insult, tissue… Expand