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Loss of normal cyclical beta 2 adrenoceptor regulation and increased premenstrual responsiveness to adenosine monophosphate in stable female asthmatic patients.
TLDR
Despite an appropriate rise in female sex hormones during the luteal period, beta 2 adrenoceptor regulation in female asthmatic subjects shows a loss of the normal cyclical pattern. Expand
Modulation of airway reactivity and peak flow variability in asthmatics receiving the oral contraceptive pill.
TLDR
Asthmatic patients receiving the OCP had attenuated cyclical change in airway reactivity as well as reduced diurnal PEFR variability, which was associated with suppression of the normal luteal phase rise in sex-hormones. Expand
Concomitant administration of low-dose prednisolone protects against in vivo beta2-adrenoceptor subsensitivity induced by regular formoterol.
TLDR
Concomitant administration of a low dose of PRED produced protection against FM-induced subsensitivity of systemic beta2-AR, as assessed by the response to inhaled salbutamol, which suggests that there is a dissociation in the dose ofPRED required to protect against beta-adrenoceptor downregulation and subsensitivity, following continuous exposure to long-actingbeta2-agonist. Expand
Paradoxical down-regulation and desensitization of beta2-adrenoceptors by exogenous progesterone in female asthmatics.
TLDR
The results show that exogenous progesterone, but not estrogen, given during the follicular phase, decreased beta2-AR density and cyclic-AMP response in female asthmatics, in contrast to the previously observed up-regulating effect of progester one seen in healthy women. Expand
Effects of exogenous female sex-steroid hormones on lymphocyte beta 2-adrenoceptors in normal females.
TLDR
It is suggested that endogenous progesterone is probably responsible for previously observed increase in Bmax during the luteal phase of the female menstrual cycle, and possible therapeutic strategies for modulation of beta 2-AR in premenstrual asthma are suggested. Expand
Expression of the beta 2 adrenoceptor partial agonist/antagonist activity of salbutamol in states of low and high adrenergic tone.
TLDR
The in vivo phenomenon of partial beta 2 agonist/antagonist activity of salbutamol may be of relevance in the setting of acute asthma if adrenergic tone is increased, since upregulation rather than downregulation was observed. Expand
Beta2-adrenoceptor regulation and function in female asthmatic patients receiving the oral combined contraceptive pill.
TLDR
The OCP did not alter beta2-adrenoceptor regulation and function in stable female asthmatic patients and further studies are required in patients who have premenstrual asthma. Expand
Effects of short-term exposure to high-dose inhaled corticosteroids on novel markers of bone metabolism
TLDR
Thus, when using sensitive markers of collagen turnover, short-term inhaled corticosteroid therapy was found paradoxically to reduced bone resorption. Expand
Effects of oral and inhaled corticosteroid on lymphocyte beta2-adrenoceptor function in asthmatic patients.
TLDR
This study confirms the previous finding of a dissociation in sensitivity between effects of inhaled corticosteroid on adrenal suppression and lymphocyte beta2-AR regulation, at least for doses up to 2 mg day-1 of fluticasone. Expand
Effect of exogenous female sex-steroid hormones on β2-adrenoceptors in healthy males
TLDR
In contrast to previously reported effects in women, female sex-steroid hormones did not appear to have any significant facilitatory effects on lymphocyte β2-AR parameters when given exogenously to healthy males. Expand
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