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Evaluation of the biocompatibility of a chitosan scaffold in mice.
- P. VandeVord, H. Matthew, S. Desilva, L. Mayton, B. Wu, P. Wooley
- Materials Science, Medicine
- Journal of biomedical materials research
- 5 March 2002
Chitosan scaffolds appear to be suitable for a variety of tissue engineering applications. This study addressed the biocompatibility of chitosan in a mouse implantation model. Porous chitosan… Expand
Inflammatory responses to orthopaedic biomaterials in the murine air pouch.
An in vivo model of the inflammatory response to orthopaedic biomaterials was used to examine cellular and cytokine responses to polymer particles of ultra high molecular weight polyethylene (UHMWPE)… Expand
Protective effects of IL-1Ra or vIL-10 gene transfer on a murine model of wear debris-induced osteolysis
The current study evaluated the protective effects of anti-inflammatory cytokine gene transfer on osteolysis provoked by orthopedic biomaterial particles using a murine model of inflammatory bone… Expand
Morphological characteristics of total joint arthroplasty-derived ultra-high molecular weight polyethylene (UHMWPE) wear debris that provoke inflammation in a murine model of inflammation.
- Allison L. Sieving, B. Wu, L. Mayton, S. Nasser, P. Wooley
- Medicine, Materials Science
- Journal of biomedical materials research. Part A
- 1 March 2003
It is recognized that the chronic inflammation in peri-prosthetic tissue that contributes to implant failure frequently is provoked by the presence of wear debris. Some wear debris is inevitable… Expand
TNF receptor gene therapy results in suppression of IgG2a anticollagen antibody in collagen induced arthritis
- P. Mukherjee, B. Wu, L. Mayton, S. Kim, P. Robbins, P. Wooley
- Annals of the rheumatic diseases
- 1 August 2003
Background: Therapeutic strategies to block tumour necrosis factor α (TNFα) activity in experimental autoimmune arthritis models and rheumatoid arthritis (RA) have proved highly successful, and… Expand
IFNgamma deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vbeta6 and Vbeta8 in arthritic joints.
BACKGROUND Transgenic deficiency in interferon gamma (IFNgamma) or IFNgamma receptor makes resistant strains of mice bearing H-2(b) or H-2(d) susceptible to collagen induced arthritis (CIA). … Expand
Murine model of prosthesis failure for the long‐term study of aseptic loosening
- S. Yang, Haiying Yu, +4 authors P. Wooley
- Journal of orthopaedic research : official…
- 2 February 2007
We examined a novel mouse model of wear debris‐induced prosthesis instability and osteolysis, and its application for the evaluation of therapy. A stainless steel or titanium‐alloy pin was implanted… Expand
IL-1Ra and vIL-10 gene transfer using retroviral vectors ameliorates particle-associated inflammation in the murine air pouch model
- S. Yang, B. Wu, L. Mayton, C. Evans, P. Robbins, P. Wooley
- Chemistry, Medicine
- Inflammation Research
- 1 July 2002
Abstract. Objective: This study examined anti-inflammatory gene therapy to ameliorate tissue responses to ultra high molecular weight polyethylene (UHMWPE) particles in the murine air pouch.¶Methods:… Expand
Ethylenediaminetetraacetic acid in ammonium hydroxide for reducing decalcification time.
Ethylenediaminetetraacetic acid (EDTA) solution is used to decalcify bone specimens for histological examination. Sodium hydroxide (NaOH) has been used to dissolve EDTA and to bring EDTA solutions to… Expand
IFNγ deficient C57BL/6 (H-2b) mice develop collagen induced arthritis with predominant usage of T cell receptor Vβ6 and Vβ8 in arthritic joints
Background: Transgenic deficiency in interferon γ (IFNγ) or IFNγ receptor makes resistant strains of mice bearing H-2b or H-2d susceptible to collagen induced arthritis (CIA). Objective: To determine… Expand