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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
MARIJUANA and many of its constituent cannabinoids influence the central nervous system (CNS) in a complex and dose-dependent manner1,2. Although CNS depression and analgesia are well documentedExpand
Localization of cannabinoid receptor mRNA in rat brain
Cannabinoid receptor mRNA was localized in adult rat brain by 35S‐tailed oligonucleotide probes and in situ hybridization histochemistry. Labelling is described as uniform or non‐uniform depending onExpand
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
The physiologic activity of (-)-delta 9-tetrahydrocannabinol, the most active component of marijuana, and of many synthetic cannabimimetics may be mediated either through receptor binding andExpand
Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains
The distribution and density of cannabinoid receptor binding and messenger RNA expression in aged human brain were examined in several forebrain and basal ganglia structures. In vitro binding ofExpand
Molecular aspects of cannabinoid receptors.
  • L. Matsuda
  • Biology, Medicine
  • Critical reviews in neurobiology
  • 1997
Two cannabinoid receptors are reviewed with regard to their primary structure, ligand-binding properties, and signal transduction systems. Both receptors have been cloned; therefore, the expressionExpand
Neurotoxicity of amphetamines and their metabolites.
When amphetamine or an analog is administered in repeated high doses, neurochemical deficits in both the dopaminergic and serotonergic systems of selected areas of the brain are observed.Expand
Characterization of dopaminergic influence on striatal-nigral neurotensin systems
Dopamine depletion by treatment with alpha-methyl-p-tyrosine had no effect on methamphetamine-mediated increases in striatal neurotensin (NT) concentrations but significantly attenuated nigralExpand
Expression of the CB1 cannabinoid receptor in macrophage-like cells from brain tissue: immunochemical characterization by fusion protein antibodies
Antibodies designed to recognize a 74 amino acid sequence of the N- or C-terminal domain of the rat CB1 cannabinoid receptor detected a 58 kDa protein in immunoblots of brain and various cells knownExpand
Effects of cocaine on methamphetamine-induced neurochemical changes: characterization of cocaine as a monoamine uptake blocker.
Many of the rewarding aspects of cocaine are thought to be due to the ability of this stimulant to block reuptake of monoamines. However, because of its ability also to cause transmitter release, itExpand
In vitro release of tritiated monoamines from rat CNS tissue by the neurotoxic compound 1-methyl-phenyl-tetrahydropyridine.
The effects of the neurotoxic compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (1-MPTP), on monoamine release was determined using slices of rat corpus striatum or cerebral cortex preloadedExpand