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Structure of a cannabinoid receptor and functional expression of the cloned cDNA
The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.
Localization of cannabinoid receptor mRNA in rat brain
The localization of cannabinoid receptor mRNA indicates that sensory, motor, cognitive, limbic, and autonomic systems should all be influenced by the activation of this receptor by either exogenous cannabimimetics, including marijuana, or the yet unknown endogenous “cannabinoid” ligand.
Cannabinoid agonists stimulate both receptor- and non-receptor-mediated signal transduction pathways in cells transfected with and expressing cannabinoid receptor clones.
- C. Felder, J. Veluz, H. Williams, E. M. Briley, L. Matsuda
- Biology, ChemistryMolecular pharmacology
- 1 November 1992
Binding constants measured using CP55,940 indicated that the rat and human cloned cannabinoid receptors were similar to native cannabinoid receptors measured in brain and neural cell lines, and cannabinoid agonists can stimulate signaling pathways through both receptor- and non-receptor-mediated pathways in the same cell.
Cannabinoid receptor binding and messenger RNA expression in human brain: An in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains
Molecular aspects of cannabinoid receptors.
- L. Matsuda
- BiologyCritical reviews in neurobiology
Although receptors appear to be involved in cannabimimetic-induced modulation of immune cell function, the receptor subtype that is principally involved in specific effects is difficult to determine because both receptors are often coexpressed in the same cells.
Neurotoxicity of amphetamines and their metabolites.
- J. Gibb, M. Johnson, I. Elayan, H. Lim, L. Matsuda, G. Hanson
- Biology, PsychologyNIDA research monograph
When amphetamine or an analog is administered in repeated high doses, neurochemical deficits in both the dopaminergic and serotonergic systems of selected areas of the brain are observed and persist in rats and nonhuman primates for extended periods of time after the drug is discontinued.
Characterization of dopaminergic influence on striatal-nigral neurotensin systems
Effects of cocaine on methamphetamine-induced neurochemical changes: characterization of cocaine as a monoamine uptake blocker.
- G. Hanson, L. Matsuda, J. Gibb
- Biology, ChemistryThe Journal of pharmacology and experimental…
- 1 August 1987
Cocaine was evaluated as a blocker of dopamine and 5-hydroxytryptamine uptake processes by determining the in vivo effect of concurrent administrations of cocaine on the neurochemical effects of methamphetamine treatments and these findings demonstrated that cocaine greatly attenuated or blocked decreases in striatal and cortical tryptophan hydroxylase activities and concentrations by multiple and single methamphetamine administrations.
In vitro release of tritiated monoamines from rat CNS tissue by the neurotoxic compound 1-methyl-phenyl-tetrahydropyridine.