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Ang-2-VEGF-A CrossMab, a Novel Bispecific Human IgG1 Antibody Blocking VEGF-A and Ang-2 Functions Simultaneously, Mediates Potent Antitumor, Antiangiogenic, and Antimetastatic Efficacy
Data establish Ang-2-VEGF-A CrossMab as a promising antitumor, antiangiogenic, and antimetastatic agent for the treatment of cancer.
18F-labeled FECNT: a selective radioligand for PET imaging of brain dopamine transporters.
Interaction of Isoflurane with the Dopamine Transporter
In vitro experiments indicate that DAT is trafficked into the cell by isoflurane without changing the total amount of DAT in the striatum, and the PET data are consistent with this finding, provided that intracellular DAT acquires a conformation that has low affinity for [18F]FECNT.
In vivo measurement of gadolinium diffusivity by dynamic contrast‐enhanced MRI: A preclinical study of human xenografts
- T. Koh, S. Hartono, C. Thng, T. Lim, L. Martarello, Q. Ng
- Medicine, BiologyMagnetic Resonance in Medicine
- 1 January 2013
G gadolinium diffusivity is proposed as an alternative parameter for quantifying tracer transport within necrotic tumor regions to explore the use of Fick's law of diffusion for analysis of dynamic contrast‐enhanced MRI data in the Necrotic regions.
Synthesis of syn- and anti-1-amino-3-[18F]fluoromethyl-cyclobutane-1-carboxylic acid (FMACBC), potential PET ligands for tumor detection.
- L. Martarello, J. McConathy, M. Goodman
- Biology, ChemistryJournal of medicinal chemistry
- 26 April 2002
This work demonstrates that like anti-1-amino-3-[18F]fluoromethyl-cyclobutane- 1-carboxylic acid, [18F]-16 and [ 18F]17 are excellent candidates for imaging brain tumors.
Screening of new antioxidant molecules using flow cytometry.
A flow cytometry technique to evaluate the antioxidative properties of molecules on living cells, using a stable murine-murine hybridoma (Mark 3) cell line routinely cultured, found the selenated molecule 18 was found to be 10 times more active than Ebselen but 10 000 times less active than vitamin E.
An evaluation of the brain distribution of [11C]GSK1034702, a muscarinic-1 (M1) positive allosteric modulator in the living human brain using positron emission tomography
In primate and human PET studies designed to evaluate the transport of a novel M1 allosteric agonist across the BBB, good brain uptake and BBB passage consistent with passive diffusion or active influx is demonstrated.
Fluorinase mediated C-(18)F bond formation, an enzymatic tool for PET labelling.
The fluorinase enzyme from S. cattleya is applied as a catalyst for the efficient incorporation of [18F]-fluoride into [18F]-5'-fluoro-5'-deoxyadenosine, [18F]-5'-fluoro-5'-deoxyinosine and…
Self‐administration of cocaine and the cocaine analog RTI‐113: Relationship to dopamine transporter occupancy determined by PET neuroimaging in rhesus monkeys
The results suggest that the pharmacokinetic profile of RTI‐113 (i.e., long‐acting) may influence its ability to maintain self‐administration, and therefore its abuse liability, andTherefore, high DAT occupancy is required for RTi‐113 to reduce cocaine‐maintained responding.
Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor
The utility of 11C-GSK215083 as a promising PET radioligand for probing the 5-HT6 receptor in vivo in both preclinical and clinical species is demonstrated.