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The effect of self-sampled HPV testing on participation to cervical cancer screening in Italy: a randomised controlled trial (ISRCTN96071600)
Mailing self-samplers to non-responder women aged 35–64 years may increase compliance as compared with delivering standard recall letters, and effectiveness is context specific and the strategy costs should be carefully considered.
Biological activity of a new class of rifamycins. Spiro-piperidyl-rifamycins.
In vivo (experimental infections of mice) the optimal therapeutic activity against M. tuberculosis is shown by compounds bearing 3 approximately 5 carbon atoms as a linear or branched side chain; in comparison with rifampicin, the potency of these derivatives is 2 approximately 3 times higher.
Identification of urinary metabolites of rifamycin LM 427 in man.
- A. Vigevani, M. Ballabio, B. Gioia, L. Marsili, S. Vioglio, G. Franceschi
- MedicineThe Journal of antibiotics
- 1 December 1985
The spectroscopic and chemical evidence leading to the identification of three metabolites, present in human urine, suggest that the most abundant compound 1 is equivalent to the total of metabolites 2 and 3, which are almost in the same amount; on the contrary compound 4 is present in a smaller amount.
New rifamycins modified at positions 3 and 4. Synthesis, structure and biological evaluation.
- L. Marsili, C. Pasqualucci, A. Vigevani, B. Gioia, G. Schioppacassi, G. Oronzo
- ChemistryThe Journal of antibiotics
- 1 August 1981
A number of semisynthetic rifamycin derivatives modified at positions 3 and/or 4, belonging to general structures 3, 5, and 6 are prepared and have "in vitro" antibacterial activities well comparable with that of rifampicin.
Unusual rearrangement of 3-hydrazino-rifamycins leading to the enlargement of the "natural" ansa bridge.
Novel rifamycins. III. Synthesis and antibacterial activity of 3-amidino- and of 4-aminoimidazolo[4,5-c]rifamycin derivatives.
A number of semisynthetic rifamycin derivatives modified at position 3 and/or 4, belonging to general structures 2 and 4, have been obtained and display very good antimycobacterial activity in mice.
Novel rifamycins. IV. 3-Aminomethylazinomethylrifamycins, a new class of rifamycins, endowed with remarkable antibacterial activity.
The synthesis and the biological activities of the new compounds 1, endowed with favorable pharmacokinetic behavior, are described. In particular, compound 1a has been chosen for further…
New rifamycins. II. Synthesis and biological activity of oximes, hydrazones, and semicarbazones of 3-N-(piperidin-4-one)rifamycin S.
A process for preparing 3-amino-rifamycin S and 3-amino-rifamycin SV