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The GTPase dMiro Is Required for Axonal Transport of Mitochondria to Drosophila Synapses
Synaptic differentiation of a single motor neuron: conjoint definition of transmitter release, presynaptic calcium signals, and ultrastructure
This work investigated quantal release properties, calcium signals, and ultrastructure of presynaptic terminals to elucidate factors that could account for the physiological differences in excitatory postsynaptic potentials of opener muscle in the walking legs of the crayfish.
Activity-induced changes in synaptic release sites at the crayfish neuromuscular junction
Electrophysiological studies suggest that the number of “active” synapses contributing transmitter quanta at low frequencies of stimulation increases during and after a train of high-frequency stimulation, but not all released quanta produce a voltage change in the postsynaptic muscle cell.
Quantal Size and Variation Determined by Vesicle Size in Normal and Mutant Drosophila Glutamatergic Synapses
Functional differences in synaptic strength among glutamatergic neurons of Drosophila result in part from intrinsic differences in vesicle size, which indicates that glutamate is regulated homeostatically to the same intravesicular concentration in all cases.
Morphological transformation of synaptic terminals of a phasic motoneuron by long-term tonic stimulation
It is concluded that the ongoing level of impulse activity can affect the ultrastructural differentiation of synaptic terminals and synapses of the phasic motoneuron.
Synaptic physiology and mitochondrial function in crayfish tonic and phasic motor neurons.
Evidence is provided that mitochondrial oxidative metabolism is important for sustaining synaptic transmission during maintained stimulation of tonic and phasic motor neurons and the hypothesis that synaptic fatigue resistance is dependent on mitochondrial function in crayfish motor axons is tested.
Quantal release at visualized terminals of a crayfish motor axon: Intraterminal and regional differences
- R. Cooper, C. C. Harrington, L. Marin, H. Atwood
- BiologyThe Journal of comparative neurology
- 25 November 1996
Synaptic transmission was measured at visualized terminal varicosities of the motor axon providing the sole excitatory innervation of the “opener” muscle in walking legs of crayfish (Procambarus…
Frequenin/NCS-1 and the Ca2+-channel α1-subunit co-regulate synaptic transmission and nerve-terminal growth
Overall, Frq modulates Ca2+ entry through a functional interaction with the α1 voltage-gated Ca2-channel subunit; this interaction regulates neurotransmission and nerve-terminal growth.
Synaptic Vesicles: Test for a Role in Presynaptic Calcium Regulation
SVs have a limited role, if any, in the rapid sequestration of Ca2+ within the neuronal cytosol or the synaptic microdomain, and it is concluded that SVs are not important for regulation of synaptic VGCCs.