L. Manni

Publications95
h-index30
Citations3,326
Highly Influential Citations90
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Nerve growth factor: from the early discoveries to the potential clinical use
The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central… Expand
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Circulating nerve growth factor levels are increased in humans with allergic diseases and asthma.
Nerve growth factor (NGF) serum levels were measured in 49 patients with asthma and/or rhinoconjunctivitis and/or urticaria-angioedema. Clinical and biochemical parameters, such as bronchial… Expand
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Nerve growth factor promotes corneal healing: structural, biochemical, and molecular analyses of rat and human corneas.
PURPOSE A recent clinical report demonstrated that topical nerve growth factor (NGF) treatment in patients affected by corneal neurotrophic ulcers induced epithelial and stromal healing restoring… Expand
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Nerve growth factor release by human synovial fibroblasts prior to and following exposure to tumor necrosis factor-alpha, interleukin-1 beta and cholecystokinin-8: the possible role of NGF in the…
OBJECTIVE Aim of this study was to investigate the synthesis, release and effects of nerve growth factor (NGF) in human synovial cells isolated from synovial tissue specimen from healthy and… Expand
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Nerve Growth Factor Promotes Angiogenesis and Arteriogenesis in Ischemic Hindlimbs
Background—The neurotrophin nerve growth factor (NGF) regulates neuron survival and differentiation. Implication in neovascularization is supported by statement of NGF and its high-affinity receptor… Expand
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Nerve growth factor promotes reparative angiogenesis and inhibits endothelial apoptosis in cutaneous wounds of Type 1 diabetic mice
Aims/hypothesisThe neurotrophin nerve growth factor (NGF) is pro-angiogenic and facilitates wound repair. The present study was conducted to (i) assess the statement of NGF system components in… Expand
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INHIBITION OF ENDOTOXIN-INDUCED MACROPHAGE CHEMOKINE PRODUCTION BY VASOACTIVE INTESTINAL PEPTIDE AND PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE IN VITRO AND IN VIVO
On 21-15 May, 2001 in Antalya, Turkey, the First International Meeting of Asia Minor Branch of the International Neuropeptide Society (INPS) was held in an atmosphere combining both science and… Expand
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Role of IL-1 beta and TNF-alpha in the regulation of NGF in experimentally induced arthritis in mice.
The aim of this study was to investigate the effects of IL-1 beta and TNF-alpha on NGF levels in the knee joint in experimentally induced arthritis in adult mice. Out data showed that IL-1 beta, but… Expand
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Neurotrophin presence in human coronary atherosclerosis and metabolic syndrome: a role for NGF and BDNF in cardiovascular disease?
The development of atherosclerotic cardiovascular disease is a common comorbidity in patients with the metabolic syndrome, a concurrence of cardiovascular risk factors in one individual. While… Expand
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Reduced plasma levels of NGF and BDNF in patients with acute coronary syndromes.
To test the hypothesis that neurotrophins might undergo significant changes in acute coronary syndrome (ACS), NGF and BDNF levels in sera of patients suffering of ACS and in control subjects were… Expand
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