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One molecule, many derivatives: A never‐ending interaction of melatonin with reactive oxygen and nitrogen species?
TLDR
This review focuses on melatonin metabolism which includes the synthetic rate‐limiting enzymes, synthetic sites, potential regulatory mechanisms, bioavailability in humans, mechanisms of breakdown and functions of its metabolites. Expand
Melatonin and the ovary: physiological and pathophysiological implications.
TLDR
Melatonin could become an important medication for improving ovarian function and oocyte quality, and open new opportunities for the management of several ovarian diseases. Expand
Chemical and physical properties and potential mechanisms: melatonin as a broad spectrum antioxidant and free radical scavenger.
TLDR
Under in vivo conditions, melatonin is often several times more potent than vitamin C and E in protecting tissues from oxidative injury when compared at an equivalent dosage (micromol/kg). Expand
Melatonin directly scavenges hydrogen peroxide: a potentially new metabolic pathway of melatonin biotransformation.
TLDR
Observations suggest that melatonin, a ubiquitously distributed small nonenzymatic molecule, might serve to directly detoxify H( 2)O(2) in living organisms. Expand
Biochemical reactivity of melatonin with reactive oxygen and nitrogen species
TLDR
In vitro melatonin acts as a direct free radical scavenger with the ability to detoxify both reactive oxygen and reactive nitrogen species; in vivo, it is an effective pharmacological agent in reducing oxidative damage under conditions in which excessive free radical generation is believed to be involved. Expand
High levels of melatonin in the seeds of edible plants: possible function in germ tissue protection.
TLDR
Melatonin, a free radical scavenger, might be present as an important component of its antioxidant defense system in the seed and may be essential in protecting germ and reproductive tissues of plants from oxidative damage due to ultraviolet light, drought, extremes in temperature, and environmental chemical pollutants. Expand
Functional roles of melatonin in plants, and perspectives in nutritional and agricultural science.
TLDR
Evidence indicates that melatonin has an ability to increase the production of crops and may involve the roles of melatonin in preservation of chlorophyll, promotion of photosynthesis, and stimulation of root development. Expand
Melatonin and Reproduction Revisited
TLDR
New findings related to the reported beneficial effects of melatonin on reproductive physiology beyond its now well-known role in determining the sexual status in both long-day and short-day seasonally breeding mammals are summarized. Expand
Melatonin: an ancient molecule that makes oxygen metabolically tolerable
TLDR
It is hypothesized that the initial and primary function of melatonin in photosynthetic cyanobacteria, which appeared on Earth 3.5–3.2 billion years ago, was as an antioxidant and that the melatonin‐synthesizing actions of the engulfed bacteria were retained when these organelles became mitochondria and chloroplasts, respectively. Expand
Significance of Melatonin in Antioxidative Defense System: Reactions and Products
TLDR
Melatonin in plants not only provides an alternative exogenous source of melatonin for herbivores but also suggests that melatonin may be an important antioxidant in plants which protects them from a hostile environment that includes extreme heat, cold and pollution, all of which generate free radicals. Expand
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