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Vitamin D3: a helpful immuno‐modulator
This review reports the new developments with specific reference to the metabolic and signalling mechanisms associated with the complex immune‐regulatory effects of vitamin D3 on immune cells. Expand
Molecular mechanisms involved in NAFLD progression
The potential molecular mediators initiating and supporting the progression of NASH are assessed to establish precocious diagnosis and to plan more specific treatment for this disease. Expand
The immune response to Plasmodium falciparum malaria.
Understanding of the putative mechanisms by which cytokines may mediate beneficial and harmful effects, through activation of phagocytic cells, could help to develop new treatment strategies, regardless of the emergence of parasite multidrug resistance. Expand
Chitotriosidase: the yin and yang
  • L. Malaguarnera
  • Biology, Medicine
  • Cellular and Molecular Life Sciences CMLS
  • 31 October 2006
A review is looks at the key areas of investigations addressed to further illuminate whether ChT activation might have different functional meanings in various diseases. Expand
Influence of Resveratrol on the Immune Response
A systematic understanding of how resveratrol targets multiple inflammatory components and exerts immune-regulatory effects on immune cells is offered. Expand
Heme oxygenase-1 levels and oxidative stress-related parameters in non-alcoholic fatty liver disease patients.
The induction of HO-1 is an adaptive response against oxidative damage elicited by lipid peroxidation and it may be critical in the progression of the disease. Expand
A 24-bp duplication in exon 10 of human chitotriosidase gene from the sub-Saharan to the Mediterranean area: role of parasitic diseases and environmental conditions
The present study suggests that the disappearance of parasitic diseases and the improved environmental conditions may have ensued the occurrence of a high percentage of 24-bp mutation in Sicily, in Sardinia and in other Mediterranean countries, whereas in the sub-Saharan regions (Benin and Burkina Faso), the widespread parasitic Diseases and the poor social status have contributed to maintenance of the wild-type Chit gene. Expand
Chitotriosidase gene expression in Kupffer cells from patients with non-alcoholic fatty liver disease
Human Kupffer cells in NASH patients overproduce chitotriosidase, which may play a role in increasing the risk for a poor outcome in steatohepatitis. Expand
Altered plasma cytokine levels in Alzheimer's disease: correlation with the disease progression.
The data indicate that plasma levels of these inflammatory molecules follow the degree of AD suggesting a gradual decline of immune responsiveness in AD. Expand
Evaluation of CHI3L-1 and CHIT-1 Expression in Differentiated and Polarized Macrophages
It is found that during the maturation of monocytes into macrophages, the expression of both CHI3L-1 and CHIT-1 increased exponentially over time, suggesting that in the immune response, the role of chitinase 3-like protein 1 and chitotriosidase is not restricted to innate immunity, but they are also protagonists in acquired immunity. Expand