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Phosphinic acid analogues of GABA. 2. Selective, orally active GABAB antagonists.
In 1987, 25 years after the synthesis of the potent and selective GABAB agonist baclofen (1), Kerr et al. described the first GABAB antagonist phaclofen 2. However, phaclofen and structurally similarExpand
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Organic Phosphorus Compounds. 55. The direct synthesis of hydroxymethylphosphonic acid, bis(hydroxymethyl)phosphinic acid, and methyl(hydroxymethyl)phosphinic acid
The interaction of white phosphorus and formaldehyde in water/methanol in the presence of a base is described. A mechanism accounting for the formation of HOCH2PO3H2, (HOCH2)2PO2H and CH3(HOCH2)PO2HExpand
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Molecular Structure of Phosphobenzene
THE following polyphosphines of formula (C6H5P)n have been reported in the literature: (A) m.p. 149°–150° (refs. 1–9); (B) m.p. 190° (refs. 2 and 3); (C) m.p. 252°–256° (ref. 3); (D) m.p. 260°–285°Expand
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Organic Phosphorus Compounds 60. The direct synthesis of tris(N‐substituted carbamoylethyl) phosphine oxides
The reaction of elemental white phosphorus with N-alkyl acrylamides and N,N-dialkyl acrylamides in the presence of a base is described and the physical properties of 8 new tertiary phosphine oxidesExpand
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ORGANIC PHOSPHORUS COMPOUNDS 1001 SYNTHESIS AND PROPERTIES OF N-HYDROXYCARBONYLMETHYL-AMINOMETHYL-DIALKYLPHOSPHINE OXIDES
Abstract The synthesis, physical and spectroscopic properties of N-hydroxycarbonylmethyl- and N-(1-hydroxycarbonylethyl)-aminomethyl-dimethyl (or diethyl)phosphine oxides and their esters, la, lb,Expand
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ORGANIC PHOSPHORUS COMPOUNDS 941 PREPARATION, PHYSICAL AND BIOLOGICAL PROPERTIES OF AMINO-ARYLMETHYLPHOSPHONIC- AND-PHOSPHONOUS ACIDS
Abstract The preparation, physical and spectroscopic properties of amino-arylmethylphosphonic- and -phosphonous acids, the phosphorus analogues of phenylglycine, are described. It is shown thatExpand
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Synthesis, Physical and Biological Properties of the Phosphorus Analogues Of Phenylalanine and Related Compounds
Abstract The study of phosphorus analogues of the natural a-amino acids has accelerated in the past fifteen years, not least due to the finding of molecules with useful biological activity. OurExpand
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ORGANIC PHOSPHORUS COMPOUNDS 91.1 SYNTHESIS AND PROPERTIES OF 1-AMINO-2-ARYLETHYLPHOSPHONIC AND-PHOSPHINIC ACIDS AS WELL AS -PHOSPHINE OXIDES
Abstract The preparation, physical and spectroscopic properties of l-amino-2-arylethylphosphonic, and -phosphinic acids as well as -phosphine oxides, the phosphorus analogues of phenylalanine areExpand
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