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[The pharmacological properties of karazedin].
The original agent 1,2,3,4,5,5a,6,10b-octahydroazepino-[4,5-b]indole (carazedine), an analog of the highly active antipsychotic drug carbidine, was synthesized. This agent was found to have variousExpand
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Lipid peroxidation in the caudate nuclei in experimental parkinsonian syndrome
Lipid peroxidation was investigated in adult (8-10 months of age) rat striatum with Parkinsonian syndrome induced by MPTP and its metabolite MPP+. MPTP 20 mg/kg i.p. 4 doses) produced a slightExpand
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Abnormal sleep pattern and impaired learning capacity in rats with MPTP-induced Parkinsonian syndrome
Rats with the Parkinsonian syndrome induced by systemic injection of the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) develop extrapyramidal disorders (oligokinesia, tremor, andExpand
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Condensation of O-phenylhydroxylamine with some unsymmetrical heterocyclic ketones
Abstract2-Methyl-1,2,3,4-tetrahydrobenzofuro[2,3-c]pyridine, 3,4-dihydro-1H-thiopyrano[3,4-b]benzofuran, 2,3-dihydro-4H-thiopyrano[3,2-b]benzofuran 1,1-dioxide, andExpand
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Synthesis of some 1 -oxo-1h-2,3,4,5-tetrahydro-benzofuro [3, 2-c]azepines
Condensation of O-phenylhydroxylamine with 1H-2,3,4,5,6,7-hexahydroazepine-2,4-dione in alcoholic hydrogen chloride solution gave 1-oxo-1H-2,3,4,5-tetrahydrobenzofuro[3,2-c]-azepine, while a similarExpand
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A new synthesis of benzofuro[3,2-c]pyridines
The condensation of O-phenylhydroxylamine with piperidin-4-one and 3-methylpiperidin-4-one has given 1,2,3,4-tetrahydrobenzofuro[3,2-c]pyridine and 4-methyl-1,2,3,4-tetrahydro-benzofuroExpand
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[Reception and extrareceptor binding of cytostatic serotonin antagonists by early embryos of the sea urchin Arbacia lixula].
Unfertilized eggs and early embryos of the sea urchin Arbacia lixula incubated for 60 min in a medium containing the antagonists of prenervous serotonin, i.e. inmecarb (21 microM) or imipramine (40Expand
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Experimental parkinsonian syndrome induced in rats by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
An essential condition for the development of effective treatment of parkinsonism is the creation of a pathogenetically adequate model of this highly complex syndrome. It has recently been shown thatExpand
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