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Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells.
In Drosophila, the chromosomal region 75C1-2 contains at least three genes, reaper (rpr), head involution defective (hid), and grim, that have important functions in the activation of programmed cellExpand
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Apoptotic signals delivered through the T-cell receptor of a T-cell hybrid require the immediate–early gene nur77
ENGAGEMENT of the T-cell antigen receptor (TCR) on immature thymic T cells induces death by apoptosis1–3. Although several lines of evidence indicate that apoptosis requires de novo gene expression,Expand
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Peptide inhibitors of the ice protease family arrest programmed cell death of motoneurons in vivo and in vitro
Members of the CED-3/interleukin-1 beta-converting enzyme (ICE) protease family have been implicated in cell death in both invertebrates and vertebrates. In this report, we show that peptideExpand
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Ecdysteroids regulate the release and action of eclosion hormone in the tobacco hornworm, Manduca sexta (L.)
Abstract The relationship between the ecdysteroid titre and eclosion hormone was explored for the pupal and adult ecdyses of Manduca sexta . Ecdysteroid treatment late during either moult caused aExpand
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Drosophila sickle Is a Novel grim-reaper Cell Death Activator
The Drosophila genes reaper, head involution defective (hid), and grim all reside at 75C on chromosome three and encode related proteins that have crucial functions in programmed cell death (reviewedExpand
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Drosophila Morgue is an F box/ubiquitin conjugase domain protein important for grim-reaper mediated apoptosis
In Drosophila melanogaster, apoptosis is controlled by the integrated actions of the Grim-Reaper (Grim-Rpr) and Drosophila Inhibitor of Apoptosis (DIAP) proteins (reviewed in refs 1–4). TheExpand
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The RHG motifs of Drosophila Reaper and Grim are important for their distinct cell death-inducing abilities
Reaper, Hid, and Grim are three Drosophila cell death activators that each contain a conserved NH(2)-terminal Reaper, Hid, Grim (RHG) motif. We have analyzed the importance of the RHG motifs inExpand
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Do all programmed cell deaths occur via apoptosis?
During development, large numbers of cells die by a nonpathological process referred to as programmed cell death. In many tissues, dying cells display similar changes in morphology and chromosomalExpand
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Proteasomes play an essential role in thymocyte apoptosis.
Cell death in many different organisms requires the activation of proteolytic cascades involving cytosolic proteases. Here we describe a novel requirement in thymocyte cell death for the 20SExpand
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Distinct cell killing properties of the Drosophila reaper, head involution defective, and grim genes
The Drosophila reaper, head involution defective (hid), and grim genes play key roles in regulating the activation of programmed cell death. Two useful systems for studying the functions of theseExpand
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