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Lean adolescents with increased risk for metabolic syndrome.
It is concluded that even with a BMI as low as 21 kg/m2 an inappropriate diet and low physical activity might be responsible for the high insulin levels and dislipidemias in adolescents. Expand
Association of free fatty acids with the insulin-resistant state but not with central obesity in individuals from Venezuela.
FFA levels in 47 Venezuelan individuals, men and women, 24-58 years old, were determined and the lack of elements to support the presence of hepatic IR, common to increased visceral lipolysis, might suggest that the IR present in the obese individuals studied, might be due to an increase in subcutaneous fat. Expand
Presence of impaired insulin secretion and insulin resistance in normoglycemic male subjects with family history of type 2 diabetes.
In order to demonstrate the effect of family history (FH) coexisting with obesity in insulin resistance (IR) and secretion in subjects at risk for type 2 diabetes, fasting and 2 h post-glucose loadExpand
Polimorfismo Pro12Ala del gen PPAR-γ2 y síndrome metabólico: estudio preliminar
Se concluye that the presencia del alelo Ala en individuos con sindrome metabolico mostro un efecto protector sobre el perfil lipidico. Expand
Improved triglyceride control with low glycaemic index‐high carbohydrate modified‐lipid diet in a hypertriglyceridaemic child
It is suggested that a selection of a complex digestible carbohydrate and an adequate ratio between polyunsaturated and monounsaturated fat may, in the long term, favourably improve the lipid profile. Expand
Women relatives of Hispanic patients with type 2 diabetes are more prone to exhibit metabolic disturbances.
Correlation analysis revealed strong association between BMI and WHR with skinfolds and several parameters of the carbohydrate metabolism in women, but not in men, and IR in women was possitively associated withskinfolds, SBP and lipid parameters and beta cell function with VLDL-C. Expand
[Glucose/insulin response to a glucose overload in subjects at risk for type 2 diabetes].
It is concluded that, without alteration of the glycemic response, the presence of risk factors such as obesity, dyslipidemia or family history of diabetes leads to basal hyperinsulinemia, as well as glucose stimulated hyperinsula, however the coexistence of obesity and familyHistory of diabetes, is responsible for a deficit in the insulin secretion by the pancreas. Expand
Kinetic studies of human polymorphonuclear leukocyte phosphofructokinase.
Phosphofructokinase from human polymorphonuclear leukocytes has low cooperativity and high affinity for its substrate, F-6-P. It is resistant to ATP inhibition at pH 8; however, at pH 7.1 it becomesExpand
Insulin and lipogenesis in rat adipocytes. II. Effect of high levels of insulin and glucose on lipid synthesis in isolated rat adipocytes.
The results of the present study establish that the addition of high concentrations of glucose in combination with a high level of insulin, does not modify the decrease in binding of insulin to its receptor, but the increase in lipid synthesis was completely overcome by the presence of high glucose. Expand
[Serum insulin, leptin and growth hormone levels are associated with body mass index and obesity index in adolescents].
Hyperinsulinemia, hyperleptinemia and low growth hormone levels, may be established as risk factors related to obesity markers, lipid alterations and insulin resistance that can lead to an early development of Type II diabetes and cardiovascular disease. Expand