• Publications
  • Influence
Effect of chelate treatments on kidney, bone and brain lead levels of lead-intoxicated mice.
An examination of published data describing the effect of chelating agent treatment onbrain lead levels indicates that DMSA produces a reduction in brain lead levels under all conditions examined to date. Expand
Binding of an antitumor platinum compound to cells as influenced by physical factors and pharmacologically active agents.
Theantitumoreffectiveness ofds-Ptll2 againstavariety ofanimalneoplasms is well established(8,12,13,16,17,19,21), andclinicaltrials have beenconducted atseveralinstitutions(2,7,14,20). Expand
Cadmium mobilization in vivo by intraperitoneal or oral administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid in the mouse.
The monoisoamyl ester was the most effective in removing cadmium from both the liver and the kidneys when given orally and is the first compound which is reported capable of mobilizing Cadmium in vivo from aged deposits after oral administration. Expand
Further evaluation of diethyldithiocarbamate as an antagonist of cisplatin toxicity.
N,N-disubstituted dithiocarbamates as cadmium antagonists: N-(4-methoxybenzyl)-N-dithiocarboxy-D-glucamine.
An in-vitro assessment of the interaction of MeOBDCG, BDCG and N-methyl-N-dithiocarboxy-D-glucamine with murine Cadmium-metallothionein revealed a direct relationship between the extent of cadmium depletion from Cd-MT and the relative in- vivo efficacies of the 3 analogs. Expand
Dithiocarbamate treatment of chronic cadmium intoxication in mice.
It was suggested that a Cd complexing agent of the dithiocarbamate class may have ultimate application in a provocative methodology to estimate body or organ Cd stores based upon the amount of Cd excreted following a standard dose of the chelator. Expand
Mapping the domains of the interaction of the vitamin D receptor and steroid receptor coactivator-1.
It is found that the human steroid receptor coactivator-1 (SRC-1) interacts with the VDR in a ligand-dependent manner, as demonstrated by beta-galactosidase production. Expand
Antitumor action of cis-dichlorobis(methylamine)platinum(II).
Organization Features and School Performance