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Toxic Potential of Materials at the Nanolevel
The establishment of principles and test procedures to ensure safe manufacture and use of nanomaterials in the marketplace is urgently required and achievable.
Understanding biophysicochemical interactions at the nano-bio interface.
Probing the various interfaces of nanoparticle/biological interfaces allows the development of predictive relationships between structure and activity that are determined by nanomaterial properties such as size, shape, surface chemistry, roughness and surface coatings.
Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties.
The results demonstrate that metal oxide nanoparticles induce a range of biological responses that vary from cytotoxic to cytoprotective and can only be properly understood by using a tiered test strategy such as that developed for oxidative stress and adapted to study other aspects of nanoparticle toxicity.
Use of metal oxide nanoparticle band gap to develop a predictive paradigm for oxidative stress and acute pulmonary inflammation.
It is demonstrated that it is possible to predict the toxicity of a large series of MOx nanoparticles in the lung premised on semiconductor properties and an integrated in vitro/in vivo hazard ranking model premisedon oxidative stress.
Controlled synthesis of nanostructured particles by flame spray pyrolysis
Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos.
Data show that Fe doping is a possible safe design strategy for preventing ZnO toxicity in animals and the environment.
Use of a rapid cytotoxicity screening approach to engineer a safer zinc oxide nanoparticle through iron doping.
The utility of a rapid throughput, integrated biological oxidative stress response pathway to perform hazard ranking of a small batch of metal oxide nanoparticles is demonstrated, in addition to showing how this assay can be used to improve nanosafety by decreasing ZnO dissolution through Fe doping.
Nanoparticle synthesis at high production rates by flame spray pyrolysis
Flame spray pyrolysis: An enabling technology for nanoparticles design and fabrication.
Key innovations in FSP reactor engineering and precursor chemistry have enabled flexible designs of nanostructured loosely-agglomerated powders and particulate films of pure or mixed oxides and even pure metals and alloys.