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Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis
Increasing evidence shows that oxidative stress plays an important role in the pathogenesis of multiple sclerosis (MS) and its animal model, experimental autoimmune encephalomyelitis (EAE). In recentExpand
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The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling.
Insulin-like growth factor 1 (IGF1) induces skeletal muscle hypertrophy by activating the IGF1R/IRS1/PI3K/Akt pathway. However the effect of IGF1 in differentiated muscle is limited by IRS1Expand
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Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis.
Evidence has shown that excitotoxicity may contribute to the loss of central nervous system axons and oligodendrocytes in multiple sclerosis and experimental autoimmune encephalomyelitis (EAE).Expand
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Developmental expression of α9 acetylcholine receptor mRNA in the rat cochlea and vestibular inner ear
Expression of α9 acetylcholine receptor (AChR) mRNA was studied by in situ hybridization in the rat adult and developing cochlea and vestibular inner ear. α9 AChR mRNA was first observed in cochlearExpand
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Gata4 is necessary for normal pulmonary lobar development.
Mutations of Fog2 in mice result in a phenotype that includes pulmonary lobar defects. To determine whether formation of the accessory lobe bronchus is mediated by a Gata family cofactor, weExpand
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Focal delivery of fibroblast growth factor‐1 by transfected cells induces spiral ganglion neurite targeting in vitro
Sensory cells in the cochlea of the rat transiently express acidic fibroblast growth factor (FGF‐1) during the developmental period of terminal innervation in the sensory epithelium. To explore theExpand
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Intrathecal Fas Ligand Infusion Strengthens Immunoprivilege of Central Nervous System and Suppresses Experimental Autoimmune Encephalomyelitis1
Fas ligand (FasL) is an essential molecule strongly expressed in some immunoprivileged sites, but is expressed at very low levels in normal CNS. In this study, acute experimental autoimmuneExpand
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Distribution of non‐NMDA glutamate receptor mRNAs in the developing rat cochlea
In situ hybridization was used to document the distribution of mRNA encoding six subunit isoforms of non‐N‐methyl D‐aspartic acid (NMDA) glutamate receptors (GluR1, GluR2, GluR3, GluR4, GluR5 andExpand
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Expression of acidic FGF mRNA in rat auditory brainstem during postnatal maturation.
In situ hybridization was used to investigate the mRNA distribution of acidic and basic fibroblast growth factor (aFGF and bFGF) in the auditory brainstem of neonatal and adult rats. bFGF mRNA wasExpand
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