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Quercetin reverses d-galactose induced neurotoxicity in mouse brain
- J. Lu, Yuan-Lin Zheng, L. Luo, Dong-Mei Wu, Dong-xu Sun, You-jian Feng
- Medicine, Chemistry
- Behavioural Brain Research
- 10 August 2006
It is found that quercetin dramatically elevated the GAP43 mRNA expression in the brain of D-gal-treated mice to regenerate normal function of neurons against the cellular injury caused by D-Gal. Expand
Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways.
The present results suggest that the anti-inflammatory effect of ampelopsin is due to inhibiting the interconnected ROS/Akt/IKK/NF-κB signaling pathways. Expand
Chlorogenic acid inhibits lipopolysaccharide-induced cyclooxygenase-2 expression in RAW264.7 cells through suppressing NF-kappaB and JNK/AP-1 activation.
- Jianhua Shan, Jin Fu, +4 authors Z. Yin
- Biology, Medicine
- International immunopharmacology
- 1 August 2009
CGA suppresses LPS-induced COX-2 expression via attenuating the activation of NF-kappaB and JNK/AP-1 signaling pathways suggesting that CGA, the polyphenol compound in the authors' food, could exert anti-inflammatory effects through inhibiting PGE(2) production. Expand
Human glutathione S-transferase P1-1 interacts with TRAF2 and regulates TRAF2–ASK1 signals
It is shown that GSTP1-1 physically associated with tumor necrosis factor receptor-associated factor 2 (TRAF2) in vivo and in vitro and plays an important regulatory role in TNF-α-induced signaling by forming ligand-binding interactions with TRAF2, which provides a new insight for analysing the protective effects of GSTP2 in tumor cells. Expand
Differences in microcystin production and genotype composition among Microcystis colonies of different sizes in Lake Taihu.
The authorities of water quality monitoring and drinking water supply service in Lake Taihu should be alert that the toxicity of Microcystis colony with different size was different during blooms, and the high abundance of colonies larger than 50 μm could be an indicator of relatively high bloom toxicity. Expand
Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.
- J. Lu, Yuan-Lin Zheng, Dong-Mei Wu, L. Luo, Dong-xu Sun, Qun Shan
- Chemistry, Medicine
- Biochemical pharmacology
- 1 October 2007
The results indicated that the neuroprotective effect of UA against D-gal induced neurotoxicity might be caused, at least in part, by the increase in the activity of antioxidant enzymes with a reduction in lipid peroxidation. Expand
Hsp70 inhibits lipopolysaccharide‐induced NF‐κB activation by interacting with TRAF6 and inhibiting its ubiquitination
Findings indicate that Hsp70 inhibits LPS‐induced NF‐κB activation by binding TRAF6 and preventing its ubiquitination, and results in inhibition of inflammatory mediator production, which provides a new insight for analyzing the effects of HSP70 on LPS'triggered inflammatory signal transduction pathways. Expand
Antidepressant effects of Banxia Houpu decoction, a traditional Chinese medicinal empirical formula.
The total 90% ethanol extract of the decoction was shown to possess an antidepressant activity that was close to that of Prozac, an antidepressant agent being applied clinically. Expand
Protective effect of L-theanine on carbon tetrachloride-induced acute liver injury in mice.
- W. Jiang, M. Gao, +6 authors L. Luo
- Chemistry, Medicine
- Biochemical and biophysical research…
- 1 June 2012
L-theanine protects mice against CCl(4)-induced acute liver injury through inhibiting metabolic activation of CCl (4) and preventing CCl-induced reduction of anti-oxidant capacity in mouse livers to relieve inflammatory response and hepatocyte apoptosis. Expand
HSP27 regulates IL-1 stimulated IKK activation through interacting with TRAF6 and affecting its ubiquitination.
A novel mechanism utilized by HSP27 is presented in regulating IL-1beta induced NF-small ka, CyrillicB activation via a feedback loop which includes the interaction between HSP 27 phosphorylation and ability of H SP27 to bind with TRAF6. Expand