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Spontaneous recurrent seizures after status epilepticus induced by soman in Sprague‐Dawley rats
- M. de Araujo Furtado, L. Lumley, C. Robison, L. Tong, Spencer Lichtenstein, D. Yourick
- 1 August 2010
Electroencephalographic seizures are characterized through telemetry implants in rats exposed to soman, followed by treatment with therapeutics similar to those administered after nerve agent exposure.
Hormone-neurotransmitter interactions in the control of sexual behavior
R reciprocal changes in DA and 5-HT release in different areas of the brain may promote copulation and sexual satiety, respectively.
Stoichiometric and catalytic scavengers as protection against nerve agent toxicity: a mini review.
- D. E. Lenz, David T. Yeung, J. Smith, R. Sweeney, L. Lumley, D. Cerasoli
- Chemistry, MedicineToxicology
- 20 April 2007
The results suggest that it may be possible to engineer a mutant form of PON1 with enhanced activity and stereospecificity for the most toxic nerve agent isoforms, and efforts have now been expanded to identify a catalytic protein capable of not only binding, but also rapidly hydrolyzing the standard threat nerve agents.
Acute social defeat reduces neurotrophin expression in brain cortical and subcortical areas in mice
The hypothesis that brain-derived neurotrophic factor mRNA levels are reduced by social stress is supported, and may have implications for brain plasticity and behavioral changes following social stress.
Possible acceleration of age effects on cognition following menopause.
- U. Halbreich, L. Lumley, S. Palter, C. Manning, F. Gengo, S. Joe
- Psychology, MedicineJournal of psychiatric research
- 1 May 1995
In some cognitive tests, including driving simulation, reaction time and some visuospatial tests, there is a significant acceleration in deterioration of functioning following menopause, and it is suggested that this acceleration might be associated with the lack of gonadal hormones or other reproduction-related factors which may play a protective role against age-related deterioration in some cognitive functions in women.
Opposite influence of medial preoptic D1 and D2 receptors on genital reflexes: implications for copulation.
- E. Hull, R. C. Eaton, V. Markowski, J. Moses, L. Lumley, J. A. Loucks
- Biology, MedicineLife sciences
Low levels of dopaminergic stimulation may facilitate erections and anteroflexions via D1 receptors; higher or more prolonged stimulation may shift to seminal emission via D2 receptors, which may explain the progression from erectile to ejaculatory mechanisms during copulation.
D2 receptors in the paraventricular nucleus regulate genital responses and copulation in male rats
- R. C. Eaton, V. Markowski, L. Lumley, James T. Thompson, J. Moses, E. Hull
- MedicinePharmacology Biochemistry and Behavior
- 1 May 1991
The D2 dopamine receptor agonist quinelorane, microinjected into the paraventricular nucleus (PVN), affected genital response of restrained supine male rats in a biphasic dose-dependent fashion and it is suggested that D1 receptors in the PVN may be antagonistic to D2 receptor-mediated seminal emission, and possibly also penile responses.
Social Stress Effects on Territorial Marking and Ultrasonic Vocalizations in Mice
- L. Lumley, M. L. Sipos, R. C. Charles, R. F. Charles, J. Meyerhoff
- Psychology, MedicinePhysiology & Behavior
- 1 November 1999
Examining the effects of acute SD on territorial urine marking and ultrasonic courtship vocalizations in DBA/2 male mice suggested that different mechanisms may mediate the maintenance of these behaviors.
Characterizing the behavioral effects of nerve agent-induced seizure activity in rats: Increased startle reactivity and perseverative behavior
- J. Langston, L. Wright, N. Connis, L. Lumley
- Psychology, MedicinePharmacology Biochemistry and Behavior
- 31 January 2012
It is concluded that the GD-induced seizure activity increased startle reactivity and engendered perseverative responding and that these measures are useful for assessing the long-term effects of GD exposure in rats.
Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin
- Kimberly D. Spradling, L. Lumley, C. Robison, J. Meyerhoff, J. Dillman
- Biology, MedicineJournal of Neuroinflammation
- 21 July 2011
Identifying the molecular mechanisms involved in sarin-induced neurotoxicity in these sensitive brain regions will facilitate the development of novel therapeutics that can potentially provide broad-spectrum protection in five areas of the central nervous system known to be damaged by nerve agent-induced seizure.