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Cloning and expression of a second photoreceptor-specific membrane retina guanylyl cyclase (RetGC), RetGC-2.
One of the membrane guanylyl cyclases (GCs), RetGC, is expressed predominantly in photoreceptors. No extracellular ligand has been described for RetGC, but it is sensitive to activation by a solubleExpand
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IgG4-related hypertrophic pachymeningitis: clinical features, diagnostic criteria, and treatment.
IMPORTANCE IgG4-related hypertrophic pachymeningitis (IgG4-RHP) is an increasingly recognized manifestation of IgG4-related disease, a fibroinflammatory condition that can affect virtually any organ.Expand
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General anesthesia activates BDNF-dependent neuroapoptosis in the developing rat brain
Brain-derived neurotrophic factor (BDNF) is important in supporting neuronal development. BDNF imbalance due to excessive neuronal inhibition can result in the apoptotic degeneration of developingExpand
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Circulating adiponectin levels increase in rats on caloric restriction: the potential for insulin sensitization
Caloric restriction (CR) has a well-known insulin sensitizing effect in vivo. Although this effect has been confirmed in rodents and primates for many years, its precise molecular mechanisms remainExpand
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Multisite phosphoregulation of Cdc25 activity refines the mitotic entrance and exit switches
Cyclin-dependent kinase 1 (Cdk1) kinase dephosphorylation and activation by Cdc25 phosphatase are essential for mitotic entry. Activated Cdk1 phosphorylates Cdc25 and other substrates, furtherExpand
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AQP1 expression alterations affect morphology and water transport in Schwann cells and hypoxia-induced up-regulation of AQP1 occurs in a HIF-1α-dependent manner
Aquaporin-1 (AQP1) is the principle water channel in the peripheral nervous system (PNS) and is specifically localized to Schwann cells in the PNS. However, the pathophysiological role of AQP1 inExpand
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Gastroenterology: Diaphragmatic herniation and pancreatitis
An 88-year-old veteran with a history of hypertension and dementia presented to the emergency department with acute onset severe epigastric pain and fever. Physical examination showed mild abdominalExpand
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