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The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice.
TLDR
The beneficial effects of CHF5074 treatment in young transgenic mice occurred at a stage that precedes plaque formation and were associated with a reduction in intraneuronal AβPP/Aβ and hyperphosphorylated tau. Expand
Respiratory and Psychophysical Sequelae Among Patients With COVID-19 Four Months After Hospital Discharge
TLDR
It is suggested that despite virological recovery, a sizable proportion of patients with COVID-19 experienced respiratory, functional, or psychological sequelae months after hospital discharge. Expand
Gender effect on neurodegeneration and myelin markers in an animal model for multiple sclerosis
TLDR
It is reported herein that the regulation of markers involved in demyelination and neuroprotection processes occurring during EAE, a well-established MS animal model, is gender- and time-dependent. Expand
Efficacy of Combined Photoablative-Photodynamic Diode Laser Therapy Adjunctive to Scaling and Root Planing in Periodontitis: Randomized Split-Mouth Trial with 4-Year Follow-Up.
TLDR
At 4-year follow-up, PAPD plus SRP significantly improved PD, CAL, and BOP, as well as bacterial contamination and PMN-RBC shedding in the exfoliative samples, compared with sham treatment plusSRP. Expand
Comparative evaluation of the effects of different photoablative laser irradiation protocols on the gingiva of periodontopathic patients.
TLDR
This study indicates that periodontopathogens can persist within cells outside the pocket epithelium, despite conventional periodontal treatment. Expand
In vivo nose-to-brain delivery of the hydrophilic antiviral ribavirin by microparticle agglomerates
TLDR
Powder agglomerates are a valuable approach to obtain a nasal formulation potentially attaining nose-to-brain delivery of drugs with minimal processing of the APIs and improvement of the technological and biopharmaceutical properties of micronized API and excipients, as they combine optimal flow properties for handling and dosing. Expand
Fatality rate and predictors of mortality in an Italian cohort of hospitalized COVID-19 patients
TLDR
The CFR of hospitalized patients in Northern Italy during the ascending phase of the COVID-19 pandemic approached 30% and the identification of mortality predictors might contribute to better stratification of individual patient risk. Expand
Combined photoablative and photodynamic diode laser therapy as an adjunct to non-surgical periodontal treatment: a randomized split-mouth clinical trial.
TLDR
Diode laser treatment (photoablation followed by multiple photodynamic cycles) adjunctive to conventional SRP improves healing in chronic periodontitis patients. Expand
Multi-target action of the novel anti-Alzheimer compound CHF5074: in vivo study of long term treatment in Tg2576 mice
TLDR
A profoundly diverse range of clinically relevant effects differentiating the multifunctional anti-inflammatory derivative CHF5074 from the γ-secretase inhibitor DAPT was revealed and highlighted unique mechanisms and potential targets that may be crucial for neuroprotection in mouse models of Alzheimer’s disease. Expand
Low infra red laser light irradiation on cultured neural cells: effects on mitochondria and cell viability after oxidative stress
TLDR
It is found that red light radiation protects the viability of cell culture in case of oxidative stress and stimulates neurite outgrowth, and this effect could also have positive implications for axonal protection. Expand
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