• Publications
  • Influence
Conscious Expectation and Unconscious Conditioning in Analgesic, Motor, and Hormonal Placebo/Nocebo Responses
TLDR
The effects of opposing verbal suggestions on experimental ischemic arm pain in healthy volunteers and on motor performance in Parkinsonian patients are analyzed and found that verbally induced expectations of analgesia/hyperalgesia and motor improvement/worsening antagonized completely the effects of a conditioning procedure. Expand
When words are painful: Unraveling the mechanisms of the nocebo effect
TLDR
Experimental evidence indicates that negative verbal suggestions induce anticipatory anxiety about the impending pain increase, and this verbally-induced anxiety triggers the activation of cholecystokinin which, in turn, facilitates pain transmission, and underscores the important role of cognition in the therapeutic outcome. Expand
Cognitive correlates in amyotrophic lateral sclerosis: a population-based study in Italy
TLDR
The lower educational attainment in patients with ALS-FTD indicated a possible role of cognitive reserve in ALS-related cognitive impairment, in keeping with a previous Irish study, despite the largely different genetic background of the two populations. Expand
Deep brain stimulation of the subthalamic nucleus in Parkinson's disease: effects of variation in stimulation parameters.
TLDR
Some useful indications for the electrical parameter setting in deep brain stimulation of the STN are given, and some information about the mechanism of action of deepbrain stimulation is provided. Expand
Placebo-responsive Parkinson patients show decreased activity in single neurons of subthalamic nucleus
TLDR
It is shown that placebo treatment caused reduced activity in single neurons in the subthalamic nucleus of placebo-responsive Parkinsonian patients, and changes in activity were tightly correlated with clinical improvement. Expand
Overt versus covert treatment for pain, anxiety, and Parkinson's disease
TLDR
The main finding is that when the patient is completely unaware that a treatment is being given, the treatment is less effective than when it is given overtly in accordance with routine medical practice. Expand
Pain as a nonmotor symptom of Parkinson disease: evidence from a case-control study.
TLDR
Data support the hypothesis that pain begins at clinical onset of PD or thereafter as a nonmotor feature of PD. Expand
Deep brain stimulation of the subthalamic nucleus: anatomical, neurophysiological, and outcome correlations with the effects of stimulation
TLDR
The results highlight the role of the intraoperative recording to get a more accurate localisation of the STN in surgery for Parkinson's disease, allowing the identification of the boundaries and of the extension of the nucleus. Expand
Proteome analysis of human substantia nigra in Parkinson's disease
TLDR
Results indicate a possible potentiation mechanism of afferent signals to substantia nigra following degeneration of dopaminergic neurons and the consolidated view of oxidative stress involvement in PD pathogenesis. Expand
Beyond nine years of continuous subthalamic nucleus deep brain stimulation in Parkinson's disease
TLDR
A persistent effect of deep brain stimulation of the subthalamic nucleus on the cardinal motor symptoms in advanced Parkinson's disease patients in the long‐term is indicated, however, a worsening of patients' disability, mainly due to disease progression, was observed. Expand
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