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A miniature mimic of host defense peptides with systemic antibacterial efficacy
The design and characterization of a miniature OAK composed of only 3 lysyls and 2 acyls is described that preferentially targets gram‐positive species by a bacteriostatic mode of action and supports the notion that C12(ω7)K β12 damages the plasma‐membrane architecture similarly to HDPs.
Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has been…
OAK-based cochleates as a novel approach to overcome multidrug resistance in bacteria.
- L. Livne, R. Epand, B. Papahadjopoulos-Sternberg, R. Epand, A. Mor
- BiologyFASEB journal : official publication of the…
- 1 December 2010
Single-dose administration of erythromycin coencapsulated in OAK-based cochleates has decreased drug toxicity and increased therapeutic efficacy in a dose-dependent manner, suggesting a potentially useful approach for fighting efflux-enhanced resistance mechanisms.
Antibacterial Properties and Mode of Action of a Short Acyl-Lysyl Oligomer
The data point to short OAKs as a potential source for new antibacterial compounds that can selectively affect the growth of gram-positive bacteria while circumventing potential adverse effects linked to lytic compounds.
Design and characterization of a broad -spectrum bactericidal acyl-lysyl oligomer.
OAK‐based cochleates as a novel approach to overcome multidrug resistance in bacteria
The results suggest that bacterial sensitization to antibiotics was derived mainly from the OAK's capacity to overcome the efflux‐enhanced resistance mechanism, by promoting backdoor entry of otherwise excluded antibiotics.