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Role of the conformational rigidity in the design of biomimetic antimicrobial compounds.
A link between structural flexibility of biomimetic antimicrobials and their ability to penetrate into the hydrophobic core and disrupt the integrity of bacterial lipid model membranes has beenExpand
A miniature mimic of host defense peptides with systemic antibacterial efficacy
  • H. Sarig, L. Livne, +4 authors A. Mor
  • Biology, Medicine
  • FASEB journal : official publication of the…
  • 1 June 2010
The design and characterization of a miniature OAK composed of only 3 lysyls and 2 acyls is described that preferentially targets gram‐positive species by a bacteriostatic mode of action and supports the notion that C12(ω7)K β12 damages the plasma‐membrane architecture similarly to HDPs. Expand
Antibacterial Properties and Mode of Action of a Short Acyl-Lysyl Oligomer
The data point to short OAKs as a potential source for new antibacterial compounds that can selectively affect the growth of gram-positive bacteria while circumventing potential adverse effects linked to lytic compounds. Expand
Design and characterization of a broad -spectrum bactericidal acyl-lysyl oligomer.
Investigation of OAK sequences and characterized a promising representative, designated C(12)K-3beta(10), with broad-spectrum activity and low hemotoxicity, which demonstrated the OAK's ability to significantly affect bacterial viability upon single-dose systemic treatment. Expand
OAK-based cochleates as a novel approach to overcome multidrug resistance in bacteria.
Single-dose administration of erythromycin coencapsulated in OAK-based cochleates has decreased drug toxicity and increased therapeutic efficacy in a dose-dependent manner, suggesting a potentially useful approach for fighting efflux-enhanced resistance mechanisms. Expand
OAK‐based cochleates as a novel approach to overcome multidrug resistance in bacteria
Antibiotic resistance has become a worldwide medical problem. To find new ways of overcoming this phenomenon, we investigated the role of the membrane‐active oligo‐acyl‐lysyl (OAK) sequence C12K‐7α8,Expand
A Fresh Look at Cochleate Cylinder by Freeze-Fracture Electron Microscopy: From Fusion Intermediate to Carrier of Antibiotics
The double-function of OAK-based antimicrobial peptides in forming cochleate cylinder and promoting encapsulation and effective delivery of traditional antibiotics in/by these assemblies provides an interesting approach to overcome antibiotic resistance in bacteria. Expand