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Targeted Modulation of MGMT: Clinical Implications
O6-Methylguanine DNA methyltransferase (MGMT) has been studied for >20 years as a gene that is associated with the mutagenicity and cytotoxicity induced by either methylating carcinogens or… Expand
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions.
PIK3CA, which encodes the p110α catalytic subunit of phosphatidylinositol 3-kinase α, is frequently mutated in human cancers. Most of these mutations occur at two hot-spots: E545K and H1047R located… Expand
A Small Molecule Agonist of EphA2 Receptor Tyrosine Kinase Inhibits Tumor Cell Migration In Vitro and Prostate Cancer Metastasis In Vivo
During tumor progression, EphA2 receptor can gain ligand-independent pro-oncogenic functions due to Akt activation and reduced ephrin-A ligand engagement. The effects can be reversed by ligand… Expand
Hypoxia-inducible factor-1alpha induces Twist expression in tubular epithelial cells subjected to hypoxia, leading to epithelial-to-mesenchymal transition.
Epithelial-to-mesenchymal transition (EMT) induced by chronic hypoxia is one of the critical causes of renal fibrosis. Twist, a basic helix-loop-helix transcription factor, is believed to be… Expand
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT) protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing palmitoyl acyl transferases… Expand
Cognitive Assessments for Older Adults: Which Ones are Used by Canadian Therapists and Why
- Alison Douglas, L. Liu, S. Warren, T. Hopper
- Psychology, Medicine
- Canadian journal of occupational therapy. Revue…
- 1 December 2007
Background. Occupational therapists routinely evaluate cognition in older adults, yet little is known about which assessments they use and for what purposes. Purpose. To examine the standardised and… Expand
Repopulating defect of mismatch repair-deficient hematopoietic stem cells.
Mismatch repair deficiency is associated with carcinogenesis, increased spontaneous and induced mutagenesis, and resistance to methylating agents. In humans, leukemias and lymphomas arise in the… Expand
Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
- P. Taverna, L. Liu, Amy J. Hanson, A. Monks, S. Gerson
- Biology, Medicine
- Cancer Chemotherapy and Pharmacology
Purpose and methods: The lack of a functional DNA mismatch repair (MMR) pathway has been recognized as a common characteristic of several different types of human cancers due to mutation affecting… Expand
Entry-exit and productivity change: An empirical analysis of efficiency frontiers.
- L. Liu
Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway.
A major obstacle to effective treatment with alkylating agents in cancer is the presence of elaborate mechanisms of DNA repair. For instance, the methylating therapeutic agent, temozolomide forms… Expand