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A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment
In the last decade, multiple lines of transgenic APP overexpressing mice have been created that recapitulate certain aspects of Alzheimer's disease (AD). However, none of the previously reportedExpand
Abeta levels in serum, CSF and brain, and cognitive deficits in APP + PS1 transgenic mice.
We compared beta-amyloid peptide (Abeta) levels in the serum, CSF and brain (hippocampus) and correlated these with spatial learning in APP+PS1 transgenic mice. Compared with non-transgenicExpand
Longitudinal observation on CSF Aβ42 levels in young to middle-aged amyloid precursor protein/presenilin-1 doubly transgenic mice
To relate levels of beta-amyloid42 (Abeta42) in the cerebrospinal fluid (CSF) and brain in early Alzheimer's disease, we repeatedly measured CSF Abeta42 levels in transgenic mice carrying SwedishExpand
The Effects of Long-Term Treatment with Metrifonate, a Cholinesterase Inhibitor, on Cholinergic Activity, Amyloid Pathology, and Cognitive Function in APP and PS1 Doubly Transgenic Mice
Recent studies in cell cultures have shown that modulating the cholinergic activity can influence the processing and metabolism of amyloid precursor protein (APP). To investigate whetherExpand
Tau and amyloid-related pathologies in the entorhinal cortex have divergent effects in the hippocampal circuit
The entorhinal cortex (EC) is affected early in Alzheimer's disease, an illness defined by a co-occurrence of tau and amyloid-related pathologies. How the co-occurrence of these pathologies in the ECExpand
Similar alterations in brain function for phonological and semantic processing to visual characters in Chinese dyslexia
Dyslexia in alphabetic languages has been extensively investigated and suggests a central deficit in orthography to phonology mapping in the left hemisphere. Compared to dyslexia in alphabeticExpand
Effects of (La, Sr) co-doping on electrical conduction and magnetic properties of BiFeO 3 nanoparticles
Multiferroic material as a photovoltaic material has gained considerable attention in recent years. Nanoparticles (NPs) La0.1Bi0.9−xSrxFeOy (LBSF, x = 0, 0.2, 0.4) with dopant Sr2+ ions wereExpand
Investigation of High Strength Steel for Automotive Roll-Forming Parts
In recent years, the number of automobiles has been steadily increasing, which has significantly impacted on the society and human life, and led to many social problems such as fuel crisis,Expand
Similarities and differences in brain activation and functional connectivity in first and second language reading: Evidence from Chinese learners of English
It has been evidenced that both similarities and differences exist in the brain network involved in second language reading in comparison to the first language reading. However, very few studies haveExpand
Response of glial cells and activation of complement following motorneuron degeneration induced by toxic ricin
Motor nerve transection in adult rats induce a series of metabolic and structural changes in the injured neurons as well as in surrounding glial cells; however, without substantial neuronalExpand