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2D IR provides evidence for mobile water molecules in β-amyloid fibrils
The motion of water molecules close to amide groups causes their vibrational frequencies to vary rapidly in time. These variations are uniquely sensed by 2-dimensional infrared spectroscopy (2D IR).Expand
Crystal structure of Arabidopsis glutamyl-tRNA reductase in complex with its stimulator protein
Significance The glutamyl-tRNA reductase (GluTR)-catalyzed reduction of glutamyl-tRNA is the rate-limiting and a pivotal regulation step in the tetrapyrrole biosynthetic pathway. InExpand
Two-dimensional infrared spectra of isotopically diluted amyloid fibrils from Aβ40
The 2D IR spectra of the amide-I vibrations of amyloid fibrils from Aβ40 were obtained. The matured fibrils formed from strands having isotopic substitution by 13C18O at Gly-38, Gly-33, Gly-29, orExpand
Boronic Acid-Based Approach for Separation and Immobilization of Glycoproteins and Its Application in Sensing
Glycoproteins influence a broad spectrum of biological processes including cell-cell interaction, host-pathogen interaction, or protection of proteins against proteolytic degradation. The analysis ofExpand
Structural Diversity of the Microbial Surfactin Derivatives from Selective Esterification Approach
Surfactin originated from genus Bacillus is composed of a heptapeptide moiety bonded to the carboxyl and hydroxyl groups of a β-hydroxy fatty acid and it can be chemically modified to prepare theExpand
Degradation of unmethylated miRNA/miRNA*s by a DEDDy-type 3′ to 5′ exoribonuclease Atrimmer 2 in Arabidopsis
  • X. Wang, Yuan Wang, +12 authors Guodong Ren
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 25 June 2018
Significance The steady-state levels of miRNAs are under sophisticated control to ensure their proper functions such as development and responses to environmental stimuli. Nevertheless, enzymesExpand
Biochemical Characterization of Xylanases from Streptomyces sp. B6 and Their Application in the Xylooligosaccharide Production from Viscose Fiber Production Waste.
  • L. Liu, M. Xu, +8 authors Weifeng Liu
  • Chemistry, Medicine
  • Journal of agricultural and food chemistry
  • 27 February 2020
Enzymatic hydrolysis of xylan represents a promising way to produce xylooligosaccharide (XOS), which is a novel ingredient in functional food. However, the recalcitrance of xylan in naturalExpand
Discovery of novel sulfonamides as potent and selective inhibitors against human and mouse 11β-hydroxysteroid dehydrogenase type 1
Several classes of non-steroid 11β-HSD1 inhibitors have been developed as promising treatments for Type 2 Diabetes (T2D). Using a human 11β-HSD1 selective inhibitor as a starting point, we designedExpand
Label-free electrochemical DNA sensing with a one-target-multitriggered hybridization chain reaction strategy.
A one-target-multitriggered hybridization chain reaction (MHCR) strategy was designed for ultrasensitive electrochemical detection of DNA by combining the isothermal strand-displacement polymeraseExpand
Direct Liquid Chromatography/Mass Spectrometry Analysis for Complete Characterization of Recombinant Adeno-Associated Virus Capsid Proteins.
The requirement for robust analytical methods to characterize adeno-associated virus (AAV) vectors is immediate, as the field advances more AAV gene therapies into the clinic and ontoExpand