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A general, extracorporeal immunoadsorption method to increase the tumor-to-normal tissue ratio in radioimmunoimaging and radioimmunotherapy.
- K. Norrgren, S. Strand, R. Nilsson, L. Lindgren, H. Sjögren
- Medicine, BiologyJournal of nuclear medicine : official…
- 1 March 1993
This study proves that an important reduction in background activity, and thereby an improvement in the tumor-to-background ratio, can be achieved by using this generally applicable, biotin-avidin ECIA method.
Extracorporeal immunoadsorption therapy on rats. In vivo depletion of specific antibodies
- R. Nilsson, L. Lindgren, P. Lilliehorn
- Biology, MedicineClinical and experimental immunology
- 1 December 1990
The antibody levels returned to pre‐adsorption levels after 4–5 days, or in some cases even exceeded the titres before treatment, which resulted in an antibody depletion of about 90–95%.
Extracorporeal immunoadsorption compared to avidin chase: enhancement of tumor-to-normal tissue ratio for biotinylated rhenium-188-chimeric BR96.
- J. Chen, S. Strand, J. Tennvall, L. Lindgren, C. Hindorf, H. Sjögren
- BiologyJournal of nuclear medicine : official…
- 1 December 1997
The ECIA approach, with direct removal of unbound circulating biotinylated 188Re-chiBR96, thus can rapidly improve and maintain T/N ratios without overloading the liver with radioactivity, in contrast to avidin chase.
Blood Pharmacokinetics of Various Monoclonal Antibodies Labeled with a New Trifunctional Chelating Reagent for Simultaneous Conjugation with 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N‴-Tetraacetic Acid…
Different antibodies labeled with the trifunctional chelator 1033 and 111In did not exhibit different blood pharmacokinetics, which means that the pharmacokeretics could be predicted irrespective of the IgG1 antibody chosen.
Extracorporeal immunoadsorption from whole blood based on the avidin-biotin concept. Evaluation of a new method.
The WBIA method was as effective as ECIA, but technically simpler, safer and more reliable, as compared with extracorporeal immunoadsorption (ECIA).
Improving radioimmonotargeting of tumors. Variation in the amount of L6 MAb administered, combined with an immunoadsorption system (ECIA).
Injection of larger amounts of MAb, probably causing a higher degree of tumor saturation, will not necessarily improve the T/N ratio after ECIA.
Comparison of 125I- and (111)In-labeled monoclonal antibody BR96 for tumor targeting in combination with extracorporeal immunoadsorption.
- M. Garkavij, J. Tennvall, S. Strand
- BiologyClinical cancer research : an official journal of…
- 1 October 1999
The results indicate that (111)In/(90Y)-labeled BR96-biotin could be more advantageous than 125I/131I for radioimmunotargeting/radioimmunotherapy in combination with ECIA due to better activity retention by the tumor.
Enhanced radioimmunotargeting of 125I-labeled L6-biotin monoclonal antibody (MAb) by combining preload of cold L6 MAb and subsequent immunoadsorption in rats.
The combined procedure resulted both in an increased uptake and prolonged persistence of 125I-labeled L6-biotin in the SR tumors and also in a reduction of corresponding uptake values in organs critical for radiation.
A general extracorporeal immunoadsorption method to increase tumor‐to‐tissue ratio
The authors here report on the development of new concept using a general method for ECIA based on biotinylated MoAb adsorbed on an avidin column.