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MicroRNA targeting specificity in mammals: determinants beyond seed pairing.
- A. Grimson, K. Farh, W. K. Johnston, P. Garrett-engele, L. Lim, D. Bartel
- Biology, Medicine
- Molecular cell
- 6 July 2007
Mammalian microRNAs (miRNAs) pair to 3'UTRs of mRNAs to direct their posttranscriptional repression. Important for target recognition are approximately 7 nt sites that match the seed region of the… Expand
Prediction of Plant MicroRNA Targets
- Matthew W Rhoades, B. J. Reinhart, L. Lim, C. Burge, Bonnie Bartel, D. Bartel
- Medicine, Biology
- 23 August 2002
We predict regulatory targets for 14 Arabidopsis microRNAs (miRNAs) by identifying mRNAs with near complementarity. Complementary sites within predicted targets are conserved in rice. Of the 49… Expand
Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
MicroRNAs (miRNAs) are a class of noncoding RNAs that post-transcriptionally regulate gene expression in plants and animals. To investigate the influence of miRNAs on transcript levels, we… Expand
An Abundant Class of Tiny RNAs with Probable Regulatory Roles in Caenorhabditis elegans
Two small temporal RNAs (stRNAs), lin-4 andlet-7, control developmental timing in Caenorhabditis elegans. We find that these two regulatory RNAs are members of a large class of 21- to 24-nucleotide… Expand
The microRNAs of Caenorhabditis elegans.
MicroRNAs (miRNAs) are an abundant class of tiny RNAs thought to regulate the expression of protein-coding genes in plants and animals. In the present study, we describe a computational procedure to… Expand
A microRNA component of the p53 tumour suppressor network
A global decrease in microRNA (miRNA) levels is often observed in human cancers, indicating that small RNAs may have an intrinsic function in tumour suppression. To identify miRNA components of… Expand
Computational inference of homologous gene structures in the human genome.
With the human genome sequence approaching completion, a major challenge is to identify the locations and encoded protein sequences of all human genes. To address this problem we have developed a new… Expand
Vertebrate MicroRNA Genes
MicroRNAs (miRNAs) are an abundant class of ∼22-nucleotide (nt) noncoding RNAs, some of which are known to control the expression of other genes at the posttranscriptional level ([1–4]). We… Expand
The Widespread Impact of Mammalian MicroRNAs on mRNA Repression and Evolution
Thousands of mammalian messenger RNAs are under selective pressure to maintain 7-nucleotide sites matching microRNAs (miRNAs). We found that these conserved targets are often highly expressed at… Expand
A computational analysis of sequence features involved in recognition of short introns
Splicing of short introns by the nuclear pre-mRNA splicing machinery is thought to proceed via an “intron definition” mechanism, in which the 5′ and 3′ splice sites (5′ss, 3′ss, respectively) are… Expand