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Surface Hydration: Principles and Applications Toward Low-fouling/nonfouling Biomaterials
Surface resistance to nonspecific protein adsorption, cell/bacterial adhesion, and biofilm formation is critical for the development and performance of biomedical and analytical devices. SignificantExpand
Strong repulsive forces between protein and oligo (ethylene glycol) self-assembled monolayers: a molecular simulation study.
TLDR
Results show that a tightly bound water layer adjacent to the OEG-SAMs is mainly responsible for the large repulsive hydration force. Expand
Molecular simulation study of water interactions with oligo (ethylene glycol)-terminated alkanethiol self-assembled monolayers.
TLDR
It appears that there is a correlation between OEG surface resistance to protein adsorption and the surface density of OEG chains, which leads to a large number of tightly bound water molecules around O EG chains and the rapid mobility of hydrated SAM chains. Expand
Strong resistance of phosphorylcholine self-assembled monolayers to protein adsorption: insights into nonfouling properties of zwitterionic materials.
TLDR
The strong resistance of zwitterionic phosphorylcholine (PC) self-assembled monolayers (SAMs) to protein adsorption is shown and key factors leading to their nonfouling behavior are examined using both experimental and molecular simulation techniques. Expand
Effect of film thickness on the antifouling performance of poly(hydroxy-functional methacrylates) grafted surfaces.
TLDR
The excellent antifouling ability and long-term stability ofpolyHEMA and polyHPMA brushes make them, especially for polyHEMA, effective and stable antifOUling materials for usage in blood-contacting devices. Expand
Achieving highly effective nonfouling performance for surface-grafted poly(HPMA) via atom-transfer radical polymerization.
TLDR
An improved two-step method to immobilize initiator thiols on a gold substrate for the surface-initiated atom-transfer radical polymerization (SI-ATRP) of hydroxypropyl methacrylate (HPMA) is introduced. Expand
Improved method for the preparation of carboxylic acid and amine terminated self-assembled monolayers of alkanethiolates.
TLDR
Both SAMs prepared with the improved method show better quality in terms of surface chemical composition, roughness, and wettability as measured by X-ray photoelectron spectroscopy, atomic force microscopy, and contact angle, respectively. Expand
Binding characteristics between polyethylene glycol (PEG) and proteins in aqueous solution.
TLDR
This work provides new evidence to demonstrate the existence of interactions between PEG and proteins in aqueous solution, which is important not only for better understanding of the structure-activity relationship of PEG both in solution and on surfaces, but also for the rational design of new PEG-based materials for specific applications. Expand
Structural, morphological, and kinetic studies of β-amyloid peptide aggregation on self-assembled monolayers.
TLDR
A postulated mechanism is proposed to describe the structure and kinetics of A β aggregation from aqueous solution to the SAMs, providing valuable insights into Aβ aggregation on biological cell membranes. Expand
Alzheimer Abeta(1-42) monomer adsorbed on the self-assembled monolayers.
TLDR
A collection of molecular docking and molecular dynamics simulations are presented to study the conformational dynamics and adsorption behavior of Abeta monomer on the self-assembled monolayer (SAM), in comparison to Abeta structure in bulk solution. Expand
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