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A long-range Shh enhancer regulates expression in the developing limb and fin and is associated with preaxial polydactyly.
TLDR
It is shown that the chromosome 7q36 associated preaxial polydactyly, a frequently observed congenital limb malformation, results from point mutations in a Shh regulatory element, a regulator that lies within intron 5 of the Lmbr1 gene 1 Mb from the target gene Shh. Expand
IccTA: Detecting Inter-Component Privacy Leaks in Android Apps
TLDR
IccTA, a static taint analyzer to detect privacy leaks among components in Android applications goes beyond state-of-the-art approaches by supporting inter- component detection and propagating context information among components, which improves the precision of the analysis. Expand
Glucose–TOR signalling reprograms the transcriptome and activates meristems
TLDR
Systems, cellular and genetic analyses uncover TOR phosphorylation of E2Fa transcription factor for an unconventional activation of S-phase genes, and glucose-signalling defects in e2fa root meristems, establishing pivotal roles of glucose–TOR signalling in unprecedented transcriptional networks wiring central metabolism and biosynthesis for energy and biomass production. Expand
Distributed topology control for power efficient operation in multihop wireless ad hoc networks
TLDR
This work proposes a simple distributed algorithm where each node makes local decisions about its transmission power and these local decisions collectively guarantee global connectivity and gives an approximation scheme in which the power consumption of each route can be made arbitrarily close to the optimal by carefully choosing the parameters. Expand
Exon Array Profiling Detects EML4-ALK Fusion in Breast, Colorectal, and Non–Small Cell Lung Cancers
TLDR
Findings show the recurrence of EML4-ALK fusion in multiple solid tumors and further substantiate its role in tumorigenesis, as well as elucidate the functional significance of the gene. Expand
Oxidative stress and mitochondrial dysfunction in Alzheimer's disease.
TLDR
Evidence not only demonstrates the full spectrum of oxidative damage to neuronal macromolecules, but also reveals the occurrence of oxidative events early in the course of the disease and prior to the formation of the pathology, which support an important role of oxidative stress in AD. Expand
Detection of Severe Acute Respiratory Syndrome Coronavirus in the Brain: Potential Role of the Chemokine Mig in Pathogenesis
TLDR
Direct evidence is provided that SARS human coronavirus is capable of infecting the central nervous system, and that Mig might be involved in the brain immunopathology of SARS. Expand
The Accuracy and Precision of Position and Orientation Tracking in the HTC Vive Virtual Reality System for Scientific Research
TLDR
The varying offset between the virtual and the physical tracking space makes the HTC Vive at present unsuitable for scientific experiments that require accurate visual stimulation of self-motion through a virtual world, but it may be suited for other experiments that do not have this requirement. Expand
A Frequency-Fixed SOGI-Based PLL for Single-Phase Grid-Connected Converters
Second-order generalized integrator (SOGI) based phase-locked loops (PLLs) are widely used for grid synchronization in single-phase grid-connected power converters. Previously, the estimatedExpand
Possible involvement of the novel CPI‐17 protein in protein kinase C signal transduction of rabbit arterial smooth muscle
TLDR
The results indicate that phosphorylation ofCP‐17 by PKC stimulates binding of CPI‐17 to and subsequent inhibition of MLC phosphatase, which implies that CPI‐ 17 accounts largely for the heretofore unknown signalling pathway between PKC and inhibited MLCosphatase. Expand
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